The fate of tritium labeled GM1 ganglioside injected in mice

P. Orlando, G. Cocciante, G. Ippolito, P. Massari, S. Roberti, G. Tettamanti

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.

Original languageEnglish
Pages (from-to)759-773
Number of pages15
JournalPharmacological Research Communications
Volume11
Issue number9
DOIs
Publication statusPublished - 1979

Fingerprint

G(M1) Ganglioside
Tritium
Spinal Cord
Kidney
Muscles
Membranes
Water
Liver
Brain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Orlando, P., Cocciante, G., Ippolito, G., Massari, P., Roberti, S., & Tettamanti, G. (1979). The fate of tritium labeled GM1 ganglioside injected in mice. Pharmacological Research Communications, 11(9), 759-773. https://doi.org/10.1016/S0031-6989(79)80047-8

The fate of tritium labeled GM1 ganglioside injected in mice. / Orlando, P.; Cocciante, G.; Ippolito, G.; Massari, P.; Roberti, S.; Tettamanti, G.

In: Pharmacological Research Communications, Vol. 11, No. 9, 1979, p. 759-773.

Research output: Contribution to journalArticle

Orlando, P, Cocciante, G, Ippolito, G, Massari, P, Roberti, S & Tettamanti, G 1979, 'The fate of tritium labeled GM1 ganglioside injected in mice', Pharmacological Research Communications, vol. 11, no. 9, pp. 759-773. https://doi.org/10.1016/S0031-6989(79)80047-8
Orlando P, Cocciante G, Ippolito G, Massari P, Roberti S, Tettamanti G. The fate of tritium labeled GM1 ganglioside injected in mice. Pharmacological Research Communications. 1979;11(9):759-773. https://doi.org/10.1016/S0031-6989(79)80047-8
Orlando, P. ; Cocciante, G. ; Ippolito, G. ; Massari, P. ; Roberti, S. ; Tettamanti, G. / The fate of tritium labeled GM1 ganglioside injected in mice. In: Pharmacological Research Communications. 1979 ; Vol. 11, No. 9. pp. 759-773.
@article{63acfb1d52f4499da2a6b911706929ad,
title = "The fate of tritium labeled GM1 ganglioside injected in mice",
abstract = "3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.",
author = "P. Orlando and G. Cocciante and G. Ippolito and P. Massari and S. Roberti and G. Tettamanti",
year = "1979",
doi = "10.1016/S0031-6989(79)80047-8",
language = "English",
volume = "11",
pages = "759--773",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press",
number = "9",

}

TY - JOUR

T1 - The fate of tritium labeled GM1 ganglioside injected in mice

AU - Orlando, P.

AU - Cocciante, G.

AU - Ippolito, G.

AU - Massari, P.

AU - Roberti, S.

AU - Tettamanti, G.

PY - 1979

Y1 - 1979

N2 - 3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.

AB - 3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.

UR - http://www.scopus.com/inward/record.url?scp=0018611932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018611932&partnerID=8YFLogxK

U2 - 10.1016/S0031-6989(79)80047-8

DO - 10.1016/S0031-6989(79)80047-8

M3 - Article

C2 - 531082

AN - SCOPUS:0018611932

VL - 11

SP - 759

EP - 773

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 9

ER -