3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.
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