The fate of tritium labeled GM1 ganglioside injected in mice

P. Orlando, G. Cocciante, G. Ippolito, P. Massari, S. Roberti, G. Tettamanti

Research output: Contribution to journalArticle

Abstract

3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water.

Original languageEnglish
Pages (from-to)759-773
Number of pages15
JournalPharmacological Research Communications
Volume11
Issue number9
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Pharmacology

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    Orlando, P., Cocciante, G., Ippolito, G., Massari, P., Roberti, S., & Tettamanti, G. (1979). The fate of tritium labeled GM1 ganglioside injected in mice. Pharmacological Research Communications, 11(9), 759-773. https://doi.org/10.1016/S0031-6989(79)80047-8