The feature of Metabolic Syndrome in HIV naive patients is not the same of those treated: Results from a prospective study

Paolo Bonfanti, Giuseppe Vittorio De Socio, Elena Ricci, Andrea Antinori, Canio Martinelli, Francesca Vichi, Giovanni Penco, Giordano Madeddu, Giancarlo Orofino, Laura Valsecchi, Stefano Rusconi, Barbara Menzaghi, Daria Pocaterra, Tiziana Quirino

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolic Syndrome (MS) is a common disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. Its prevalence among HIV-infected people is still debated. Besides, how antiretroviral therapy and HIV infection per se are related to MS is still unclear. All treatment-naïve patients attending scheduled visits at CISAI group hospitals between January and December 2007 were eligible for the study. Patients without MS at enrolment were followed-up for 3 years or until they developed MS, diagnosed according to the National Cholesterol Education Program (NCEP) definition. The main objective was to assess the 3-years incidence of MS. MS was evaluated for 188 subjects. Out of them, 62 (33.0%) had started HAART at enrolment, whereas 67 (35.6%) more started during the observation. 59 (31.4%) were still treatment-naive at the study end. MS was newly diagnosed in 14 patients. The incidence was 2.60 cases/100 person-years (95% CI 1.47-4.51), 2.75 (1.11-5.72) among HAART-naïve patients and 2.65 (1.23-5.03) in subjects on HAART. Blood pressure did not change in the study period, whereas in naive patients the HDL level significantly lowered (median -6.0 vs. 4.0, P

Original languageEnglish
Pages (from-to)348-353
Number of pages6
JournalBiomedicine and Pharmacotherapy
Volume66
Issue number5
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Antiretroviral therapy
  • Cardiovascular risk
  • HIV
  • Metabolic syndrome

ASJC Scopus subject areas

  • Pharmacology

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