The fifth cranial nerve in headaches

European Headache Federation School of Advanced Studies (EHF-SAS), J. C.A. Edvinsson, Alessandro Viganò, A. Alekseeva, R. Arruda, E. Alieva, C. De Luca, N. D'Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina, G. Vanderschueren, L. Zvaune, A. P. AndreouK. A. Haanes

Research output: Contribution to journalReview articlepeer-review


The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

Original languageEnglish
Number of pages1
JournalThe journal of headache and pain
Issue number1
Publication statusPublished - Jun 5 2020


  • CGRP
  • Fifth cranial nerve
  • Headache
  • Migraine pathophysiology
  • Treatments
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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