The first European interdisciplinary Ewing sarcoma research summit

Heinrich Kovar, Javier Alonso, Pierre Aman, Dave N T Aryee, Jozef Ban, Sue A. Burchill, Stefan Burdach, Enrique De Alava, Olivier Delattre, Uta Dirksen, Argyro Fourtouna, Simone Fulda, Lee J. Helman, David Herrero-Martin, Pancras C. Pancras, Udo Kontny, Elizabeth R. Lawlor, Stephen L. Lessnick, Antonio Llombart-Bosch, Markus MetzlerRichard Moriggl, Stephan Niedan, Jenny Potratz, Françoise Redini, Günther H. Günther, Lucia T. Riedmann, Claudia Rossig, Beat W. Schäfer, Raphaela Schwentner, Katia Scotlandi, Poul H. Sorensen, Martin S. Staege, Franck Tirode, Jeffrey Toretsky, Selena Ventura, Angelika Eggert, Ruth Ladenstein

Research output: Contribution to journalArticle

Abstract

The European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.

Original languageEnglish
Article numberArticle 54
JournalFrontiers in Oncology
Volume2 MAY
DOIs
Publication statusPublished - 2012

Keywords

  • Animal models
  • Biomarkers
  • Drug screen
  • Epigenetics
  • Ewing sarcoma
  • Genomics
  • Prognosis
  • Sarcomagenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Kovar, H., Alonso, J., Aman, P., Aryee, D. N. T., Ban, J., Burchill, S. A., Burdach, S., De Alava, E., Delattre, O., Dirksen, U., Fourtouna, A., Fulda, S., Helman, L. J., Herrero-Martin, D., Pancras, P. C., Kontny, U., Lawlor, E. R., Lessnick, S. L., Llombart-Bosch, A., ... Ladenstein, R. (2012). The first European interdisciplinary Ewing sarcoma research summit. Frontiers in Oncology, 2 MAY, [Article 54]. https://doi.org/10.3389/fonc.2012.00054