The first steps towards the era of personalised vaccinology: Predicting adverse reactions

P. Pellegrino, F. S. Falvella, V. Perrone, C. Carnovale, T. Brusadelli, M. Pozzi, S. Antoniazzi, S. Cheli, C. Perrotta, E. Clementi, S. Radice

Research output: Contribution to journalArticle

Abstract

Until now, the occurrence of adverse reactions among individuals inoculated with identical vaccines has been ascribed to unpredictable stochastic processes. Recent advances in pharmacogenomics indicate that some features of host response to immunisation are influenced by genetic traits, henceforth predictable. The ability to predict the adverse reaction to vaccination would represent an important step towards the development of personalised vaccinology and could enhance public confidence in the safety of vaccines. Herein, we have reviewed all the available information on the association between genetic variants and the risk for healthy subjects to develop adverse reactions.

Original languageEnglish
Pages (from-to)284-287
Number of pages4
JournalPharmacogenomics Journal
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 26 2015

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ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics
  • Medicine(all)

Cite this

Pellegrino, P., Falvella, F. S., Perrone, V., Carnovale, C., Brusadelli, T., Pozzi, M., Antoniazzi, S., Cheli, S., Perrotta, C., Clementi, E., & Radice, S. (2015). The first steps towards the era of personalised vaccinology: Predicting adverse reactions. Pharmacogenomics Journal, 15(3), 284-287. https://doi.org/10.1038/tpj.2014.57