The fork head transcription factor Fkh5/Mf3 is a developmental marker gene for superior colliculus layers and derivatives of the hindbrain somatic afferent zone

Gonzalo Alvarez-Bolado, Francesco Cecconi, Roland Wehr, Peter Gruss

Research output: Contribution to journalArticle

Abstract

Fork head-5 (Fkh5; also known as Mf3 and TWH) is a transcription factor of the winged helix family. As part of an extended project to understand the function of this protein in the developing mouse brain, in the present work we have used Fkh5/Mf3 expression as a marker to study the development of the midbrain and hindbrain. In the midbrain, Fkh5/Mf3 is expressed in the superior colliculus, in the ventricular layer of the inferior colliculus and in the isthmus. In the superior colliculus, Fkh5/Mf3 is expressed by cells of layers 4a and 4c since early in development. In the hindbrain, Fkh5/Mf3 is a longitudinal marker (as opposed to a transverse or rhombomeric one), since it labels nuclei belonging to the somatic afferent zone (ventral cochlear nucleus, cuneate and external cuneate nuclei, principal and spinal nuclei of the trigeminal). In addition, Fkh5/Mf3 is expressed by the developing endopiriform nucleus and by the olivary pretectal nucleus. The results suggest that Fkh5/Mf3 has an early role in the lamination of the tectum and in the longitudinal differentiation of the hindbrain.

Original languageEnglish
Pages (from-to)205-215
Number of pages11
JournalDevelopmental Brain Research
Volume112
Issue number2
DOIs
Publication statusPublished - Feb 5 1999

Keywords

  • Fork head
  • Midbrain/hindbrain junction
  • Nomenclature
  • Regionalization

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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