The "Frail" Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections

Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Cristina Carresi, Federica Scarano, Francesca Bosco, Saverio Nucera, Stefano Ruga, Maria Caterina Zito, Rocco Mollace, Ernesto Palma, Massimo Fini, Carolina Muscoli, Vincenzo Mollace

Research output: Contribution to journalReview article

Abstract

The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. The endothelial cells are the major vital components of the BBB able to preserve the brain homeostasis. These cells are situated along the demarcation line between the bloodstream and the brain. Therefore, an alteration or the progressive disruption of the endothelial layer may clearly impair the brain homeostasis. The proper functioning of the brain endothelial cells is generally ensured by two elements: (1) the presence of junction proteins and (2) the preservation of a specific polarity involving an apical-luminal and a basolateral-abluminal membrane. This review intends to identify the molecular mechanisms underlying BBB function and their changes occurring in early stages of neurodegenerative processes in order to develop novel therapeutic strategies aimed to counteract neurodegenerative disorders.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 10 2018

Fingerprint

Neurodegenerative diseases
blood-brain barrier
Endothelial cells
Blood-Brain Barrier
Neurodegenerative Diseases
brain
Brain
Endothelial Cells
homeostasis
cells
Homeostasis
Pericytes
Oligodendroglia
Microglia
neurons
Astrocytes
Neurons
Extracellular Matrix
polarity
disorders

Keywords

  • Blood-Brain Barrier/cytology
  • Cell Communication
  • Cell Polarity
  • Endothelial Cells/cytology
  • Humans
  • Intercellular Junctions/metabolism
  • Membrane Proteins/metabolism
  • Neurodegenerative Diseases/metabolism

Cite this

The "Frail" Brain Blood Barrier in Neurodegenerative Diseases : Role of Early Disruption of Endothelial Cell-to-Cell Connections. / Maiuolo, Jessica; Gliozzi, Micaela; Musolino, Vincenzo; Scicchitano, Miriam; Carresi, Cristina; Scarano, Federica; Bosco, Francesca; Nucera, Saverio; Ruga, Stefano; Zito, Maria Caterina; Mollace, Rocco; Palma, Ernesto; Fini, Massimo; Muscoli, Carolina; Mollace, Vincenzo.

In: International Journal of Molecular Sciences, Vol. 19, No. 9, 10.09.2018.

Research output: Contribution to journalReview article

Maiuolo, J, Gliozzi, M, Musolino, V, Scicchitano, M, Carresi, C, Scarano, F, Bosco, F, Nucera, S, Ruga, S, Zito, MC, Mollace, R, Palma, E, Fini, M, Muscoli, C & Mollace, V 2018, 'The "Frail" Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections', International Journal of Molecular Sciences, vol. 19, no. 9. https://doi.org/10.3390/ijms19092693
Maiuolo, Jessica ; Gliozzi, Micaela ; Musolino, Vincenzo ; Scicchitano, Miriam ; Carresi, Cristina ; Scarano, Federica ; Bosco, Francesca ; Nucera, Saverio ; Ruga, Stefano ; Zito, Maria Caterina ; Mollace, Rocco ; Palma, Ernesto ; Fini, Massimo ; Muscoli, Carolina ; Mollace, Vincenzo. / The "Frail" Brain Blood Barrier in Neurodegenerative Diseases : Role of Early Disruption of Endothelial Cell-to-Cell Connections. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 9.
@article{b888da3c9ebc4172845981f3b5a527db,
title = "The {"}Frail{"} Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections",
abstract = "The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. The endothelial cells are the major vital components of the BBB able to preserve the brain homeostasis. These cells are situated along the demarcation line between the bloodstream and the brain. Therefore, an alteration or the progressive disruption of the endothelial layer may clearly impair the brain homeostasis. The proper functioning of the brain endothelial cells is generally ensured by two elements: (1) the presence of junction proteins and (2) the preservation of a specific polarity involving an apical-luminal and a basolateral-abluminal membrane. This review intends to identify the molecular mechanisms underlying BBB function and their changes occurring in early stages of neurodegenerative processes in order to develop novel therapeutic strategies aimed to counteract neurodegenerative disorders.",
keywords = "Blood-Brain Barrier/cytology, Cell Communication, Cell Polarity, Endothelial Cells/cytology, Humans, Intercellular Junctions/metabolism, Membrane Proteins/metabolism, Neurodegenerative Diseases/metabolism",
author = "Jessica Maiuolo and Micaela Gliozzi and Vincenzo Musolino and Miriam Scicchitano and Cristina Carresi and Federica Scarano and Francesca Bosco and Saverio Nucera and Stefano Ruga and Zito, {Maria Caterina} and Rocco Mollace and Ernesto Palma and Massimo Fini and Carolina Muscoli and Vincenzo Mollace",
year = "2018",
month = "9",
day = "10",
doi = "10.3390/ijms19092693",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "9",

}

TY - JOUR

T1 - The "Frail" Brain Blood Barrier in Neurodegenerative Diseases

T2 - Role of Early Disruption of Endothelial Cell-to-Cell Connections

AU - Maiuolo, Jessica

AU - Gliozzi, Micaela

AU - Musolino, Vincenzo

AU - Scicchitano, Miriam

AU - Carresi, Cristina

AU - Scarano, Federica

AU - Bosco, Francesca

AU - Nucera, Saverio

AU - Ruga, Stefano

AU - Zito, Maria Caterina

AU - Mollace, Rocco

AU - Palma, Ernesto

AU - Fini, Massimo

AU - Muscoli, Carolina

AU - Mollace, Vincenzo

PY - 2018/9/10

Y1 - 2018/9/10

N2 - The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. The endothelial cells are the major vital components of the BBB able to preserve the brain homeostasis. These cells are situated along the demarcation line between the bloodstream and the brain. Therefore, an alteration or the progressive disruption of the endothelial layer may clearly impair the brain homeostasis. The proper functioning of the brain endothelial cells is generally ensured by two elements: (1) the presence of junction proteins and (2) the preservation of a specific polarity involving an apical-luminal and a basolateral-abluminal membrane. This review intends to identify the molecular mechanisms underlying BBB function and their changes occurring in early stages of neurodegenerative processes in order to develop novel therapeutic strategies aimed to counteract neurodegenerative disorders.

AB - The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. The endothelial cells are the major vital components of the BBB able to preserve the brain homeostasis. These cells are situated along the demarcation line between the bloodstream and the brain. Therefore, an alteration or the progressive disruption of the endothelial layer may clearly impair the brain homeostasis. The proper functioning of the brain endothelial cells is generally ensured by two elements: (1) the presence of junction proteins and (2) the preservation of a specific polarity involving an apical-luminal and a basolateral-abluminal membrane. This review intends to identify the molecular mechanisms underlying BBB function and their changes occurring in early stages of neurodegenerative processes in order to develop novel therapeutic strategies aimed to counteract neurodegenerative disorders.

KW - Blood-Brain Barrier/cytology

KW - Cell Communication

KW - Cell Polarity

KW - Endothelial Cells/cytology

KW - Humans

KW - Intercellular Junctions/metabolism

KW - Membrane Proteins/metabolism

KW - Neurodegenerative Diseases/metabolism

U2 - 10.3390/ijms19092693

DO - 10.3390/ijms19092693

M3 - Review article

C2 - 30201915

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 9

ER -