The Frailty Index in centenarians and their offspring

Beatrice Arosio; E Ferri; M Casati; D Mari; G Vitale; M Cesari

doi:10.1007/s40520-019-01283-7

The Frailty Index in centenarians and their offspring

Beatrice Arosio, E Ferri, M Casati, D Mari, G Vitale, M Cesari

Research output: Contribution to journal › Article › peer-review

Abstract

Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.

Original language	English
Pages (from-to)	1685-1688
Number of pages	4
Journal	Aging clinical and experimental research
Volume	31
Issue number	11
DOIs	https://doi.org/10.1007/s40520-019-01283-7
Publication status	Published - Nov 2019

Keywords

Adult Children
Aged
Aged, 80 and over
Aging/physiology
Case-Control Studies
Cohort Studies
Cross-Sectional Studies
Female
Frail Elderly
Frailty/diagnosis
Geriatric Assessment/methods
Humans
Male
Middle Aged

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@article{918be8eec2354d7da4362799cdbfce23,

title = "The Frailty Index in centenarians and their offspring",

abstract = "Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.",

keywords = "Adult Children, Aged, Aged, 80 and over, Aging/physiology, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Female, Frail Elderly, Frailty/diagnosis, Geriatric Assessment/methods, Humans, Male, Middle Aged",

author = "Beatrice Arosio and E Ferri and M Casati and D Mari and G Vitale and M Cesari",

year = "2019",

month = nov,

doi = "10.1007/s40520-019-01283-7",

language = "English",

volume = "31",

pages = "1685--1688",

journal = "Aging clinical and experimental research",

issn = "1594-0667",

publisher = "Springer International Publishing AG",

number = "11",

}

TY - JOUR

T1 - The Frailty Index in centenarians and their offspring

AU - Arosio, Beatrice

AU - Ferri, E

AU - Casati, M

AU - Mari, D

AU - Vitale, G

AU - Cesari, M

PY - 2019/11

Y1 - 2019/11

N2 - Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.

AB - Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.

KW - Adult Children

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Case-Control Studies

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Frail Elderly

KW - Frailty/diagnosis

KW - Geriatric Assessment/methods

KW - Humans

KW - Male

KW - Middle Aged

U2 - 10.1007/s40520-019-01283-7

DO - 10.1007/s40520-019-01283-7

M3 - Article

C2 - 31359370

VL - 31

SP - 1685

EP - 1688

JO - Aging clinical and experimental research

JF - Aging clinical and experimental research

SN - 1594-0667

IS - 11

ER -