Abstract
Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.
Original language | English |
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Pages (from-to) | 1685-1688 |
Number of pages | 4 |
Journal | Aging clinical and experimental research |
Volume | 31 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2019 |
Keywords
- Adult Children
- Aged
- Aged, 80 and over
- Aging/physiology
- Case-Control Studies
- Cohort Studies
- Cross-Sectional Studies
- Female
- Frail Elderly
- Frailty/diagnosis
- Geriatric Assessment/methods
- Humans
- Male
- Middle Aged