The Frailty Index in centenarians and their offspring

Beatrice Arosio, E Ferri, M Casati, D Mari, G Vitale, M Cesari

Research output: Contribution to journalArticlepeer-review


Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.

Original languageEnglish
Pages (from-to)1685-1688
Number of pages4
JournalAging clinical and experimental research
Issue number11
Publication statusPublished - Nov 2019


  • Adult Children
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Case-Control Studies
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Frail Elderly
  • Frailty/diagnosis
  • Geriatric Assessment/methods
  • Humans
  • Male
  • Middle Aged


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