The Framingham prediction rule is not valid in a European population of treated hypertensive patients

Sylvie Bastuji-Garin, Anne Deverly, Dominique Moyse, Alain Castaigne, Giuseppe Mancia, Peter W. De Leeuw, Luis M. Ruilope, Talma Rosenthal, Gilles Chatellier

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Stratification of population groups according to cardiovascular risk level is recommended for primary prevention. Objective: To assess whether the Framingham models could accurately predict the absolute risk of coronary heart disease (CHD) and stroke in a large cohort of middle-aged European patients with hypertension, and rank individual patients according to actual risk. Design: A prospective cohort study comparing the actual risk with that predicted by either the Framingham equations or models derived from the INSIGHT study. Patients and setting: From the INSIGHT prospective trial, conducted in eight countries of Western Europe and Israel, we selected 4407 European patients younger than 75 years without previous cardiovascular events. Interventions: None. Main outcome measures: Major cardiovascular events. Results: In this population (45% men, mean age 64.1 years), 124 (2.8%) patients had CHD and 96 (2.2%) had strokes after a median follow-up of 3.7 years. Overestimation of absolute CHD risk by the Framingham equation was observed in all countries (from 2% in the UK to 7% in France), whereas predicted risk of stroke was close to the actual risk. However, patients in the highest risk quintile within each country had a threefold greater risk of a cardiovascular event than those in the lowest quintile. Conclusions: The Framingham models should not be used to predict absolute CHD risk in the European population as a whole. However, these models may be used within each country, provided that cut-off points defining high-risk patients have been determined within each country.

Original languageEnglish
Pages (from-to)1973-1980
Number of pages8
JournalJournal of Hypertension
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Coronary heart disease
  • European cohort
  • Risk factors
  • Risk prediction
  • Stroke

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

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