The frequency of CD127+ hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection

Eui Cheol Shin, Su Hyung Park, Michelina Nascimbeni, Marian Major, Laura Caggiari, Valli de Re, Stephen M. Feinstone, Charles M. Rice, Barbara Rehermann

Research output: Contribution to journalArticlepeer-review

Abstract

T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.

Original languageEnglish
Pages (from-to)4772-4777
Number of pages6
JournalJournal of Virology
Volume87
Issue number8
DOIs
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Immunology
  • Virology

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