The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults

Reina Armamento-Villareal, Neil Wingkun, Lina E. Aguirre, Vibhati Kulkarny, Nicola Napoli, Georgia Colleluori, Clifford Qualls, Dennis T. Villareal

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Fat mass and obesity-associated (FTO) gene polymorphisms have been reported to be associated with differences in BMI, obesity, and type 2 diabetes. However, previous studies have been predominantly conducted in younger individuals across a spectrum of body weights, whereas little information is available on the older population. We examined the association of FTO gene polymorphisms with cardiometabolic risks among adults who were both obese (BMI≥30 kg/m) and older (age≥65 years). METHODS: A total of 165 frail, obese older adults were genotyped for FTO (rs9939609 and rs8050136) single nucleotide polymorphisms and studied for associations with body weight and body composition, components and prevalence of the metabolic syndrome, insulin response to an oral glucose tolerance test, and levels of adipocytokines (e.g. leptin) and vitamin D. RESULTS: Carriers of the A allele (CA/AA) of the FTO single nucleotide polymorphism rs8050136 had lower body weight, BMI, body fat, and trunk fat than those without the A allele (CC genotype; all P’s

Original languageEnglish
JournalPharmacogenetics and Genomics
DOIs
Publication statusAccepted/In press - Dec 24 2015

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

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    Armamento-Villareal, R., Wingkun, N., Aguirre, L. E., Kulkarny, V., Napoli, N., Colleluori, G., Qualls, C., & Villareal, D. T. (Accepted/In press). The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults. Pharmacogenetics and Genomics. https://doi.org/10.1097/FPC.0000000000000201