The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia

A. Reif, E. Scarpini, E. Venturelli, T. Töpner, C. Fenoglio, K. P. Lesch, D. Galimberti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The genetic underpinnings of frontotemporal dementia (FTD), a rare yet early onset disorder still remains elusive. As FTD is characterized by a serotonergic deficit in the frontal lobe, and as some symptoms of FTD resemble conditions of monoamino oxidase A (MAO-A) deficiency, MAO-A is an attractive candidate gene for case-control association studies of FTD. We have thus ascertained 62 Italian FTD patients and 151 controls matched to age and genotyped them for a functional promoter polymorphism, termed MAOA-uVNTR. However, no significant differences were observed between patients and controls. Bearing in mind the caveat of the small patient sample size, our data nevertheless argue against a major genetic role of MAO-A polymorphism in FTD.

Original languageEnglish
Pages (from-to)637-639
Number of pages3
JournalEuropean Journal of Neurology
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Frontotemporal Dementia
Oxidoreductases
Frontal Lobe
Sample Size
Case-Control Studies
Genes

Keywords

  • Genetics
  • MAOA uVNTR
  • Monoamine oxidase
  • Promoter polymorphism
  • Risk factor
  • VNTR

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia. / Reif, A.; Scarpini, E.; Venturelli, E.; Töpner, T.; Fenoglio, C.; Lesch, K. P.; Galimberti, D.

In: European Journal of Neurology, Vol. 15, No. 6, 06.2008, p. 637-639.

Research output: Contribution to journalArticle

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AU - Lesch, K. P.

AU - Galimberti, D.

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