The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Jasper C A Broen, Marieke J H Coenen, Blanca Rueda, Torsten Witte, Leonid Padyukov, Lars Klareskog, Roger Hesselstrand, Dirk M. Wuttge, Carmen Simeon, Norberto Ortego-Centeno, Miguel A. González-Gay, Anna Pros, Nicholas Hunzelman, Gabriela Riemekasten, Alexander Kreuter, Madelon Vonk, Rafaella Scorza, Lorenzo Beretta, Paulo Airò, Piet L C M Van RielRobert Kimberly, Javier Martin, Jeffrey Edberg, Timothy R D J Radstake

Research output: Contribution to journalArticle

Abstract

Objective. To investigate the role of the Fc αRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc αRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the Fc αRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)446-449
Number of pages4
JournalJournal of Rheumatology
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • CD89
  • Fc RI
  • IgA
  • Rheumatoid arthritis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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    Broen, J. C. A., Coenen, M. J. H., Rueda, B., Witte, T., Padyukov, L., Klareskog, L., Hesselstrand, R., Wuttge, D. M., Simeon, C., Ortego-Centeno, N., González-Gay, M. A., Pros, A., Hunzelman, N., Riemekasten, G., Kreuter, A., Vonk, M., Scorza, R., Beretta, L., Airò, P., ... Radstake, T. R. D. J. (2011). The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility. Journal of Rheumatology, 38(3), 446-449. https://doi.org/10.3899/jrheum.100427