The fundamental contribution of Jan C. Waldenström to the discovery and study of the so-called "Waldenström macroglobulinemia"

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Waldenström macroglobulinemia may be said to be characterized cheifly by two features: (1) a striking increase in IgM globulin of the "monoclonal gammapathy" type and (2) an abnormal bone marrow characterized by either a leukemic or leukemic-like picture, in which lymphocytes of various types are prominent. All the other features, hemorrhagic, hemolytic, rheologic (viscosity syndrome) must be considered as secondary manifestations. This historical review article summarizes the fundamental contribution of Jan Costa Waldenström to the discovery and study of this lymphoproliferative disorder.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalLeukemia Research
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • History of medicine
  • Macroglobulinemia
  • Waldenström

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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