The future therapeutic potential of histone demethylases

A critical analysis

Gioacchino Natoli, Giuseppe Testa, Francesca De Santa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Once regarded as an irreversible modification, the methylation of histone protein tails has recently been highlighted following the identification of enzymes capable of histone demethylation in response to developmental or environmental cues. An awareness of the dynamic nature of histone modification has stimulated interest in the concept that drugs targeting histone methylation/demethylation might provide treatments for cancer, inflammation and metabolic disorders. However, epigenetic therapies that target histone demethylation are at the concept stage. Histone demethylases and their potential as therapeutic targets are discussed in this review.

Original languageEnglish
Pages (from-to)607-615
Number of pages9
JournalCurrent Opinion in Drug Discovery and Development
Volume12
Issue number5
Publication statusPublished - Sep 2009

Fingerprint

Histone Demethylases
Histone Code
Histones
Methylation
Drug Delivery Systems
Epigenomics
Cues
Therapeutics
Inflammation
Enzymes
Neoplasms
Proteins

Keywords

  • Histone demethylation
  • Histone methylation
  • Hydroxylation
  • JmjC domain
  • Substrate specificity
  • Transcription

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

The future therapeutic potential of histone demethylases : A critical analysis. / Natoli, Gioacchino; Testa, Giuseppe; De Santa, Francesca.

In: Current Opinion in Drug Discovery and Development, Vol. 12, No. 5, 09.2009, p. 607-615.

Research output: Contribution to journalArticle

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