The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

N. Panera, A.E. Tozzi, A. Alisi

Research output: Contribution to journalArticlepeer-review

Abstract

G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic. © 2020, Springer Nature Switzerland AG.
Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalDrugs
Volume80
Issue number10
DOIs
Publication statusPublished - 2020

Keywords

  • guanine quadruplex
  • helicase
  • antivirus agent
  • methyltransferase
  • Nsp13 protein, SARS-CoV
  • NSP3 protein, SARS-CoV-2
  • RNA helicase
  • viral protein
  • antiviral activity
  • Article
  • coronavirus disease 2019
  • Coronavirus infection
  • enzyme activity
  • pandemic
  • Severe acute respiratory syndrome coronavirus 2
  • virus replication
  • Betacoronavirus
  • drug repositioning
  • genetics
  • human
  • metabolism
  • virus genome
  • virus pneumonia
  • Antiviral Agents
  • Coronavirus Infections
  • Drug Repositioning
  • G-Quadruplexes
  • Genome, Viral
  • Humans
  • Methyltransferases
  • Pandemics
  • Pneumonia, Viral
  • RNA Helicases
  • Viral Nonstructural Proteins

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