The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

S. Goldwurm, A. Di Fonzo, E. J. Simons, C. F. Rohé, M. Zini, M. Canesi, S. Tesei, A. Zecchinelli, A. Antonini, C. Mariani, N. Meucci, G. Sacilotto, F. Sironi, G. Salani, J. Ferreira, H. F. Chien, E. Fabrizio, N. Vanacore, A. Dalla Libera, F. StocchiC. Diroma, P. Lamberti, C. Sampaio, G. Meco, E. Barbosa, A. M. Bertoli-Avella, G. J. Breedveld, B. A. Oostra, G. Pezzoli, V. Bonifati

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (

Original languageEnglish
JournalJournal of Medical Genetics
Volume42
Issue number11
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Goldwurm, S., Di Fonzo, A., Simons, E. J., Rohé, C. F., Zini, M., Canesi, M., Tesei, S., Zecchinelli, A., Antonini, A., Mariani, C., Meucci, N., Sacilotto, G., Sironi, F., Salani, G., Ferreira, J., Chien, H. F., Fabrizio, E., Vanacore, N., Dalla Libera, A., ... Bonifati, V. (2005). The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. Journal of Medical Genetics, 42(11).