The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

S. Goldwurm; A. Di Fonzo; E. J. Simons; C. F. Rohé; M. Zini; M. Canesi; S. Tesei; A. Zecchinelli; A. Antonini; C. Mariani; N. Meucci; G. Sacilotto; F. Sironi; G. Salani; J. Ferreira; H. F. Chien; E. Fabrizio; N. Vanacore; A. Dalla Libera; F. Stocchi; C. Diroma; P. Lamberti; C. Sampaio; G. Meco; E. Barbosa; A. M. Bertoli-Avella; G. J. Breedveld; B. A. Oostra; G. Pezzoli; V. Bonifati

The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

S. Goldwurm, A. Di Fonzo, E. J. Simons, C. F. Rohé, M. Zini, M. Canesi, S. Tesei, A. Zecchinelli, A. Antonini, C. Mariani, N. Meucci, G. Sacilotto, F. Sironi, G. Salani, J. Ferreira, H. F. Chien, E. Fabrizio, N. Vanacore, A. Dalla Libera, F. StocchiC. Diroma, P. Lamberti, C. Sampaio, G. Meco, E. Barbosa, A. M. Bertoli-Avella, G. J. Breedveld, B. A. Oostra, G. Pezzoli, V. Bonifati

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (

Original language	English
Journal	Journal of Medical Genetics
Volume	42
Issue number	11
Publication status	Published - Nov 2005

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

Goldwurm, S., Di Fonzo, A., Simons, E. J., Rohé, C. F., Zini, M., Canesi, M., Tesei, S., Zecchinelli, A., Antonini, A., Mariani, C., Meucci, N., Sacilotto, G., Sironi, F., Salani, G., Ferreira, J., Chien, H. F., Fabrizio, E., Vanacore, N., Dalla Libera, A., ... Bonifati, V. (2005). The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. Journal of Medical Genetics, 42(11).

Goldwurm, S, Di Fonzo, A, Simons, EJ, Rohé, CF, Zini, M, Canesi, M, Tesei, S, Zecchinelli, A, Antonini, A, Mariani, C, Meucci, N, Sacilotto, G, Sironi, F, Salani, G, Ferreira, J, Chien, HF, Fabrizio, E, Vanacore, N, Dalla Libera, A, Stocchi, F, Diroma, C, Lamberti, P, Sampaio, C, Meco, G, Barbosa, E, Bertoli-Avella, AM, Breedveld, GJ, Oostra, BA, Pezzoli, G & Bonifati, V 2005, 'The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.', Journal of Medical Genetics, vol. 42, no. 11.

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title = "The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.",

abstract = "BACKGROUND: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (",

author = "S. Goldwurm and {Di Fonzo}, A. and Simons, {E. J.} and Roh{\'e}, {C. F.} and M. Zini and M. Canesi and S. Tesei and A. Zecchinelli and A. Antonini and C. Mariani and N. Meucci and G. Sacilotto and F. Sironi and G. Salani and J. Ferreira and Chien, {H. F.} and E. Fabrizio and N. Vanacore and {Dalla Libera}, A. and F. Stocchi and C. Diroma and P. Lamberti and C. Sampaio and G. Meco and E. Barbosa and Bertoli-Avella, {A. M.} and Breedveld, {G. J.} and Oostra, {B. A.} and G. Pezzoli and V. Bonifati",

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T1 - The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

AU - Goldwurm, S.

AU - Di Fonzo, A.

AU - Simons, E. J.

AU - Rohé, C. F.

AU - Zini, M.

AU - Canesi, M.

AU - Tesei, S.

AU - Zecchinelli, A.

AU - Antonini, A.

AU - Mariani, C.

AU - Meucci, N.

AU - Sacilotto, G.

AU - Sironi, F.

AU - Salani, G.

AU - Ferreira, J.

AU - Chien, H. F.

AU - Fabrizio, E.

AU - Vanacore, N.

AU - Dalla Libera, A.

AU - Stocchi, F.

AU - Diroma, C.

AU - Lamberti, P.

AU - Sampaio, C.

AU - Meco, G.

AU - Barbosa, E.

AU - Bertoli-Avella, A. M.

AU - Breedveld, G. J.

AU - Oostra, B. A.

AU - Pezzoli, G.

AU - Bonifati, V.

PY - 2005/11

Y1 - 2005/11

N2 - BACKGROUND: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (

AB - BACKGROUND: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (

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AN - SCOPUS:33645160640

VL - 42

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

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The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

Abstract

ASJC Scopus subject areas

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