TY - JOUR
T1 - The "gender factor" in wearing-off among patients with parkinson's disease
T2 - A post hoc analysis of DEEP study
AU - Colombo, Delia
AU - Abbruzzese, Giovanni
AU - Antonini, Angelo
AU - Barone, Paolo
AU - Bellia, Gilberto
AU - Franconi, Flavia
AU - Simoni, Lucia
AU - Attar, Mahmood
AU - Zagni, Emanuela
AU - Haggiag, Shalom
AU - Stocchi, Fabrizio
PY - 2015/1/20
Y1 - 2015/1/20
N2 - Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson's disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists' judgment (61.9% versus 53.8%, P = 0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P = 0.034). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.
AB - Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson's disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists' judgment (61.9% versus 53.8%, P = 0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P = 0.034). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.
UR - http://www.scopus.com/inward/record.url?scp=84922372132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922372132&partnerID=8YFLogxK
U2 - 10.1155/2015/787451
DO - 10.1155/2015/787451
M3 - Article
AN - SCOPUS:84922372132
VL - 2015
JO - The Scientific World Journal
JF - The Scientific World Journal
SN - 2356-6140
M1 - 787451
ER -