The gene for human peptidase A is on band 18q23 and shows triplex and uniplex dosage effect

C. Danesino, Alessandra D'Azzo, Paola Maraschio, M. Fraccaro

Research output: Contribution to journalArticlepeer-review

Abstract

Gene dosage effect for the enzyme peptidase A was studied in the red cells of subjects trisomic (seven cases) or monosomic (five cases) for the segment of chromosome 18 carrying the gene. The individual levels of enzyme activity in both groups were different from those of the controls, but with a wide overlap. The use of the ratio of the activity of each subject to the midparent activity eliminated the overlapping. The mean ratio was 0.94 for the controls, 2.36 for the trisomics, and 0.41 for the monosomics. The trisomic ratio is higher than expected on the assumption of a linear effect. Correlation with the cytogenetic data in four cases of ring 18 and one of 18q-firmly places the gene for peptidase A on band 18q23.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalHuman Genetics
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 1978

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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