The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: A multicenter case-control study

Virpi Leppä, Ida Surakka, Pentti J. Tienari, Irina Elovaara, Alastair Compston, Stephen Sawcer, Neil Robertson, Philip L. de Jager, Cristin Aubin, David A. Hafler, Annette Bang Oturai, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sørensen, Bernhard Hemmer, Sabine Cepok, Juliane Winkelmann, Heinz Erich Wichmann, Manuel Comabella, Marta F. BustamanteXavier Montalban, Tomas Olsson, Ingrid Kockum, Jan Hillert, Lars Alfredsson, An Goris, Bénédicte Dubois, Inger Lise Mero, Cathrine Smestad, Elisabeth G. Celius, Hanne F. Harbo, Sandra D'Alfonso, Laura Bergamaschi, Maurizio Leone, Giovanni Ristori, Ludwig Kappos, Stephen L. Hauser, Isabelle Cournu-Rebeix, Bertrand Fontaine, Steven Boonen, Chris Polman, Aarno Palotie, Leena Peltonen, Janna Saarela

Research output: Contribution to journalArticle

Abstract

Background: In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To refine our understanding of these associations we sought to replicate these findings in a large more extensive independent sample set of 11 populations of European origin. Principal Findings: We calculated individual and combined associations using a meta-analysis method by Kazeem and Farral (2005). We confirmed the association of rs1800693 in TNFRSF1A (p 4.19×10-7, OR 1.12, 7,665 cases, 8,051 controls) and rs17445836 near IRF8 (p 5.35×10-10, OR 0.84, 6,895 cases, 7,580 controls and 596 case-parent trios) The SNP rs17824933 in CD6 also showed nominally significant evidence for association (p 2.19×10-5, OR 1.11, 8,047 cases, 9,174 controls, 604 case-parent trios). Conclusions: Variants in TNFRSF1A and in the vicinity of IRF8 were confirmed to be associated in these independent cohorts, which supports the role of these loci in etiology of multiple sclerosis. The variant in CD6 reached genome-wide significance after combining the data with the original meta-analysis. Fine mapping is required to identify the predisposing variants in the loci and future functional studies will refine their molecular role in MS pathogenesis.

Original languageEnglish
Article numbere18813
JournalPLoS One
Volume6
Issue number4
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Leppä, V., Surakka, I., Tienari, P. J., Elovaara, I., Compston, A., Sawcer, S., Robertson, N., de Jager, P. L., Aubin, C., Hafler, D. A., Oturai, A. B., Søndergaard, H. B., Sellebjerg, F., Sørensen, P. S., Hemmer, B., Cepok, S., Winkelmann, J., Wichmann, H. E., Comabella, M., ... Saarela, J. (2011). The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: A multicenter case-control study. PLoS One, 6(4), [e18813]. https://doi.org/10.1371/journal.pone.0018813