Abstract
Coronary artery disease is a major socioeconomic problem in industrialized as well as in developing countries. Thus, many research efforts continue to address the identification of acquired and inherited risk factors of this complex disease. Recent advances in genotyping technology have made available newer and more powerful tools for the identification of susceptibility genes that in turn may provide new opportunities to evaluate the individual cardiovascular risk profile, detect novel disease pathways, and develop innovative therapeutic approaches. Replication of results is essential to establish unequivocally the impact of genetic variants in complex diseases. At the moment, only distinct but tightly linked single nucleotide polymorphisms on chromosome 9 have been consistently shown to be associated with different clinical phenotypes of coronary artery disease.
| Original language | English |
|---|---|
| Pages (from-to) | 157-162 |
| Number of pages | 6 |
| Journal | Trends in Cardiovascular Medicine |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 2008 |
Fingerprint
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The Genetic Basis of Coronary Artery Disease : From Candidate Genes to Whole Genome Analysis. / Franchini, Massimo; Peyvandi, Flora; Mannucci, Pier Mannuccio.
In: Trends in Cardiovascular Medicine, Vol. 18, No. 5, 07.2008, p. 157-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Genetic Basis of Coronary Artery Disease
T2 - From Candidate Genes to Whole Genome Analysis
AU - Franchini, Massimo
AU - Peyvandi, Flora
AU - Mannucci, Pier Mannuccio
PY - 2008/7
Y1 - 2008/7
N2 - Coronary artery disease is a major socioeconomic problem in industrialized as well as in developing countries. Thus, many research efforts continue to address the identification of acquired and inherited risk factors of this complex disease. Recent advances in genotyping technology have made available newer and more powerful tools for the identification of susceptibility genes that in turn may provide new opportunities to evaluate the individual cardiovascular risk profile, detect novel disease pathways, and develop innovative therapeutic approaches. Replication of results is essential to establish unequivocally the impact of genetic variants in complex diseases. At the moment, only distinct but tightly linked single nucleotide polymorphisms on chromosome 9 have been consistently shown to be associated with different clinical phenotypes of coronary artery disease.
AB - Coronary artery disease is a major socioeconomic problem in industrialized as well as in developing countries. Thus, many research efforts continue to address the identification of acquired and inherited risk factors of this complex disease. Recent advances in genotyping technology have made available newer and more powerful tools for the identification of susceptibility genes that in turn may provide new opportunities to evaluate the individual cardiovascular risk profile, detect novel disease pathways, and develop innovative therapeutic approaches. Replication of results is essential to establish unequivocally the impact of genetic variants in complex diseases. At the moment, only distinct but tightly linked single nucleotide polymorphisms on chromosome 9 have been consistently shown to be associated with different clinical phenotypes of coronary artery disease.
UR - http://www.scopus.com/inward/record.url?scp=51549096161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51549096161&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2008.04.003
DO - 10.1016/j.tcm.2008.04.003
M3 - Article
C2 - 18790385
AN - SCOPUS:51549096161
VL - 18
SP - 157
EP - 162
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
SN - 1050-1738
IS - 5
ER -