The genetic variant of lactase persistence C/T (13910) and blood glucose control in type 1 diabetes mellitus patients

Rossana Mineri, Giosuè Ghilardi, Simona Brambilla, Tiziana Sarno, Muriel Bologna, Serenella Valaperta, Alessandro Montanelli

Research output: Contribution to journalArticle

Abstract

Lactose intolerance is found in 70% of the world-wide population. Lactase activity gradually increases till birth and then, after the early months of life, it physiologically begins to lessen. In about 30% of the population it remains active also as an adult due to a mutation: in Europe a substitution of C with T in position 13910 of the lactase gene. Our data show that CC genotype, associated with lactase non-persistence, is found in type 1 diabetes with a high prevalence of 67%. To evaluate the "glycaemic-metabolic control" we investigated the glycosylated haemoglobin (HbA1c) values and we noted that there is no significant difference between CC (non-absorber) and CT/TT (absorber) genotypes of diabetic patients. Glutamic acid decarboxylase antibodies (GADA) are positive in 58% of diabetic patients with CC genotype: this presence could be linked to the intestinal membrane hyperpermeability.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalMediterranean Journal of Nutrition and Metabolism
Volume1
Issue number3
DOIs
Publication statusPublished - Jan 2009

Keywords

  • C/T (13910)
  • Diabetes
  • Lactase persistence
  • Lactose intolerance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

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