The genetic variant of lactase persistence C/T (13910) and blood glucose control in type 1 diabetes mellitus patients

Rossana Mineri, Giosuè Ghilardi, Simona Brambilla, Tiziana Sarno, Muriel Bologna, Serenella Valaperta, Alessandro Montanelli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Lactose intolerance is found in 70% of the world-wide population. Lactase activity gradually increases till birth and then, after the early months of life, it physiologically begins to lessen. In about 30% of the population it remains active also as an adult due to a mutation: in Europe a substitution of C with T in position 13910 of the lactase gene. Our data show that CC genotype, associated with lactase non-persistence, is found in type 1 diabetes with a high prevalence of 67%. To evaluate the "glycaemic-metabolic control" we investigated the glycosylated haemoglobin (HbA1c) values and we noted that there is no significant difference between CC (non-absorber) and CT/TT (absorber) genotypes of diabetic patients. Glutamic acid decarboxylase antibodies (GADA) are positive in 58% of diabetic patients with CC genotype: this presence could be linked to the intestinal membrane hyperpermeability.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalMediterranean Journal of Nutrition and Metabolism
Volume1
Issue number3
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Lactase
insulin-dependent diabetes mellitus
beta-galactosidase
Type 1 Diabetes Mellitus
blood glucose
Blood Glucose
Genotype
genotype
Lactose Intolerance
lactose intolerance
glycohemoglobin
Glutamate Decarboxylase
Glycosylated Hemoglobin A
glutamic acid
Population
hemoglobin
Parturition
mutation
Mutation
antibodies

Keywords

  • C/T (13910)
  • Diabetes
  • Lactase persistence
  • Lactose intolerance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

Cite this

The genetic variant of lactase persistence C/T (13910) and blood glucose control in type 1 diabetes mellitus patients. / Mineri, Rossana; Ghilardi, Giosuè; Brambilla, Simona; Sarno, Tiziana; Bologna, Muriel; Valaperta, Serenella; Montanelli, Alessandro.

In: Mediterranean Journal of Nutrition and Metabolism, Vol. 1, No. 3, 01.2009, p. 181-185.

Research output: Contribution to journalArticle

Mineri, Rossana ; Ghilardi, Giosuè ; Brambilla, Simona ; Sarno, Tiziana ; Bologna, Muriel ; Valaperta, Serenella ; Montanelli, Alessandro. / The genetic variant of lactase persistence C/T (13910) and blood glucose control in type 1 diabetes mellitus patients. In: Mediterranean Journal of Nutrition and Metabolism. 2009 ; Vol. 1, No. 3. pp. 181-185.
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