The genetics and the molecular functions of the PREP1 homeodomain transcription factor

Divya Purushothaman, Francesco Blasi

Research output: Contribution to journalArticle

Abstract

Prep1 (pKnox1) is a homeodomain transcription factor of the TALE superclass whose members can act as co-factors of Hox. Prep1 is essential for embryogenesis, but in the adult it also acts as a tumor suppressor. We describe and analyze here the available mutant mice, their phenotypes and a few discordant cases. Moreover we specify the basic rules underlying the binding of Prep1 and its TALE partners to DNA, and their plasticity during embryonic development. We finally review recent data on Prep1 which indicate a very basic cellular function at the level of DNA replication and DNA damage.

Original languageEnglish
Pages (from-to)819-825
Number of pages7
JournalInternational Journal of Developmental Biology
Volume62
Issue number11-12
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Embryonic Development
Molecular Biology
Transcription Factors
DNA Replication
DNA Damage
Phenotype
DNA
Neoplasms

Keywords

  • Epiblast
  • Pknox1
  • Prep1
  • Tumor
  • Tumor suppressor

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

Cite this

The genetics and the molecular functions of the PREP1 homeodomain transcription factor. / Purushothaman, Divya; Blasi, Francesco.

In: International Journal of Developmental Biology, Vol. 62, No. 11-12, 01.01.2018, p. 819-825.

Research output: Contribution to journalArticle

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