All genetic and epidemiologic works on migraine show an important genetic component in migraine determination. Specific transmission models are undefined, but X-linked and mitochondrial models are unlikely. The most likely kind of transmission involves more autosomal genes, dominant or recessive, with reduced penetrance and with an environmental effect. Searching for genes involved in migraine pathogenesis is to now unproductive, except for CACNL1A4 (chromosome 19) and CACNL1A3 (chromosome 1) for familial hempiplegic migraine.
|Number of pages||7|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology