The genomic landscapes of inflammation

Research output: Contribution to journalArticle

Abstract

Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalGenes and Development
Volume25
Issue number2
DOIs
Publication statusPublished - Jan 15 2011

Keywords

  • ChiP-seq
  • Chromatin
  • Inflammation
  • Macrophages
  • NF-kB
  • Pu.1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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