The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia

Giovanni Del Poeta, Emanuele Ammatuna, Serena Lavorgna, Giovanni Capelli, Serena Zaza, Fabrizio Luciano, Tiziana Ottone, Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Paola Panetta, Paolo De Fabritiis, Roberto Stasi, Adriano Venditti, Sergio Amadori, Francesco Lo Coco

Research output: Contribution to journalArticle

Abstract

Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio >0·35 and NPM1 without FLT3-ITD were significantly associated (P = 0·0001). NPM1-mutated (mt)/FLT3-ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0·0002) and a longer overall survival (OS, P = 0·00007). NPM1-mt/FLT3-ITD negative plus bax/bcl-2 > 0·35 subset showed a very high CR rate (96%), very long OS (P = 0·00005) and disease-free survival (P = 0·004). The favourable prognosis of NPM1-mt/FLT3-ITD negative patients might be explained by a higher bax/bcl-2 ratio.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalBritish Journal of Haematology
Volume149
Issue number3
DOIs
Publication statusPublished - May 2010

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Keywords

  • Acute myeloid leukaemia
  • Bax/bcl-2
  • FLT3-ITD
  • Nucleophosmin gene
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Del Poeta, G., Ammatuna, E., Lavorgna, S., Capelli, G., Zaza, S., Luciano, F., Ottone, T., Del Principe, M. I., Buccisano, F., Maurillo, L., Panetta, P., De Fabritiis, P., Stasi, R., Venditti, A., Amadori, S., & Lo Coco, F. (2010). The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia. British Journal of Haematology, 149(3), 383-387. https://doi.org/10.1111/j.1365-2141.2010.08098.x