Analisi geometrica delle lesioni benigne e maligne della mammella

Translated title of the contribution: The geometrical analysis of benign and malignant breast lesions

Fabio Grizzi, Pier Carlo Muzzio, Antonio D I Maggio, Nicola Dioguardi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. The aim of this study was to describe a computer-assisted method based on fractal dimension and the coefficient of roundness, two mathematical descriptors of irregularly shaped objects, in order to discriminate benign and malignant mammographic lesions. Material and methods. Twenty-three digitized mammograms were classified as containing benign lesions (n=12) or as containing malignant lesions (n=11) on the basis of readings by two independent radiologists. Morphometrical and fractal analysis of the breast lesions were automatically performed by a computer-assisted image analysis system. Results. The method shows, for the first time, two parameters that allow the classification of irregularly shaped objects, such as benign and malignant breast lesions. A significant increase was obtained when comparing the fractal dimension and the coefficient of roundness of benign versus malignant mammographic lesions. Discussion and conclusions. Benign and malignant breast lesions are characterized by complex morphologies. Complexity is the main property of all biological systems, including natural and pathological structures. In this study, we showed that fractal geometry allows quantitative measurement of the complex morphology of benign and malignant mammographic lesions. Furthermore, this mathematical approach may be helpful for the study of the non-linear dynamic processes involved in breast carcinogenesis.

Translated title of the contributionThe geometrical analysis of benign and malignant breast lesions
Original languageItalian
Pages (from-to)432-435
Number of pages4
JournalRadiologia Medica
Volume101
Issue number6
Publication statusPublished - Jun 2001

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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