The Gilles de la Tourette Syndrome-Quality of Life Scale for children and adolescents (C&A-GTS-QOL): Development and validation of the Italian version

Andrea E. Cavanna, Chiara Luoni, Claudia Selvini, Rosanna Blangiardo, Clare M. Eddy, Paola R. Silvestri, Paola V. Calì, Stefano Seri, Umberto Balottin, Francesco Cardona, Renata Rizzo, Cristiano Termine

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Gilles de la Tourette syndrome (GTS) is a chronic childhood-onset neuropsychiatric disorder with a significant impact on patients' health-related quality of life (HR-QOL). Cavanna et al. (Neurology 2008; 71: 1410-1416) developed and validated the first disease-specific HR-QOL assessment tool for adults with GTS (Gilles de la Tourette Syndrome-Quality of Life Scale, GTS-QOL). This paper presents the translation, adaptation and validation of the GTS-QOL for young Italian patients with GTS. METHODS: A three-stage process involving 75 patients with GTS recruited through three Departments of Child and Adolescent Neuropsychiatry in Italy led to the development of a 27-item instrument (Gilles de la Tourette Syndrome-Quality of Life Scale in children and adolescents, C&A-GTS-QOL) for the assessment of HR-QOL through a clinician-rated interview for 6-12 year-olds and a self-report questionnaire for 13-18 year-olds. RESULTS: The C&A-GTS-QOL demonstrated satisfactory scaling assumptions and acceptability. Internal consistency reliability was high (Cronbach's alpha > 0.7) and validity was supported by interscale correlations (range 0.4-0.7), principal-component factor analysis and correlations with other rating scales and clinical variables. CONCLUSIONS: The present version of the C&A-GTS-QOL is the first disease-specific HR-QOL tool for Italian young patients with GTS, satisfying criteria for acceptability, reliability and validity.

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalBehavioural Neurology
Volume27
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • behaviour
  • Gilles de la Tourette syndrome
  • quality of life
  • tics
  • wellbeing

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Neurology
  • Neurology

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  • Cite this

    Cavanna, A. E., Luoni, C., Selvini, C., Blangiardo, R., Eddy, C. M., Silvestri, P. R., Calì, P. V., Seri, S., Balottin, U., Cardona, F., Rizzo, R., & Termine, C. (2013). The Gilles de la Tourette Syndrome-Quality of Life Scale for children and adolescents (C&A-GTS-QOL): Development and validation of the Italian version. Behavioural Neurology, 27(1), 95-103. https://doi.org/10.3233/BEN-120274