The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells

Francesca Beretta, Silvia Bassani, Elena Binda, Chiara Verpelli, Lorenzo Bello, Rossella Galli, Maria Passafaro

Research output: Contribution to journalArticlepeer-review

Abstract

Glioblastoma multiforme (GBM) is the most invasive and undifferentiated type of brain tumour, and so surgical interventions are ineffective. We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-growing stem cells and low-grade glioma specimens. More remarkably, GluR2 overexpression in U-87MG cells inhibits proliferation by inactivating extracellular signal-regulated kinase (ERK)1/2-Src phosphorylation and induces apoptosis. Mechanistically, we observed that the scaffold protein GRIP is essential for the effect of GluR2 on ERK-Src inactivation. These findings indicate that the absence of the GluR2 subunit favours malignancy.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalEuropean Journal of Neuroscience
Volume30
Issue number1
DOIs
Publication statusPublished - Jul 2009

Keywords

  • ERK1/2
  • Glioma specimens
  • GRIP
  • Tumour stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

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