The glycerophosphoinositols: Cellular metabolism and biological functions

Daniela Corda, Pasquale Zizza, Alessia Varone, Beatrice Maria Filippi, Stefania Mariggiò

Research output: Contribution to journalArticlepeer-review

Abstract

The glycerophosphoinositols are cellular products of phospholipase A 2 and lysolipase activities on the membrane phosphoinositides. Their intracellular concentrations can vary upon oncogenic transformation, cell differentiation and hormonal stimulation. Specific glycerophosphodiester phosphodiesterases are involved in their catabolism, which, as with their formation, is under hormonal regulation. With their mechanisms of action including modulation of adenylyl cyclase, intracellular calcium levels, and Rho-GTPases, the glycerophosphoinositols have diverse effects in multiple cell types: induction of cell proliferation in thyroid cells; modulation of actin cytoskeleton organisation in fibroblasts; and reduction of the invasive potential of tumour cell lines. More recent investigations include their effects in inflammatory and immune responses. Indeed, the glycerophosphoinositols enhance cytokine-dependent chemotaxis in T-lymphocytes induced by SDF-1α-receptor activation, indicating roles for these compounds as modulators of T-cell signalling and T-cell responses.

Original languageEnglish
Pages (from-to)3449-3467
Number of pages19
JournalCellular and Molecular Life Sciences
Volume66
Issue number21
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Actin cytoskeleton
  • Cancer
  • Glycerophosphoinositols
  • Lipid signalling
  • Phosphoinositides
  • T-cell receptor signalling
  • Thyroid cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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