The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation

Olle Ringdén, Steven Z. Pavletic, Claudio Anasetti, A. John Barrett, Tao Wang, Dan Wang, Joseph H. Antin, Paolo Di Bartolomeo, Brian J. Bolwell, Christopher Bredeson, Mitchell S. Cairo, Robert P. Gale, Vikas Gupta, Theresa Hahn, Gregory A. Hale, Jorg Halter, Madan Jagasia, Mark R. Litzow, Franco Locatelli, David I. MarksPhilip L. McCarthy, Morton J. Cowan, Effie W. Petersdorf, James A. Russell, Gary J. Schiller, Harry Schouten, Stephen Spellman, Leo F. Verdonck, John R. Wingard, Mary M. Horowitz, Mukta Arora

Research output: Contribution to journalArticle

Abstract

Do some patients benefit from an unrelated donor(URD) transplant because of a stronger graft-versus-leukemia(GVL) effect? We analyzed 4099 patients with acute myeloid leukemia(AML), acute lym-phoblastic leukemia(ALL), and chronic myeloid leukemia(CML) undergoing a myeloablative allogeneic hematopoietic cell transplantation(HCT) from an URD(8/8 human leukocyte antigen [HLA]-matched, n = 941) or HLA-identical sibling donor(n = 3158) between 1995 and 2004 reported to the CIBMTR. In the Cox regression model, acute and chronic GVHD were added as time-dependent variables. In multivariate analysis, URD transplant recipients had a higher risk for transplantation-related mortality(TRM; relative risk [RR], 2.76; P <.001) and relapse(RR, 1.50; P <.002) in patients with AML, but not ALL or CML. Chronic GVHD was associated with a lower relapse risk in all diagnoses. Leukemia-free survival(LFS) was decreased in patients with AML without acute GVHD receiving a URD transplant(RR, 2.02; P <.001) but was comparable to those receiving HLA-identical sibling transplants in patients with ALL and CML. In patients without GVHD, multivariate analysis showed similar risk of relapse but decreased LFS for URD transplants for all 3 diagnoses. In conclusion, risk of relapse was the same(ALL, CML) or worse(AML) in URD transplant recipients compared with HLA-identical sibling transplant recipients, suggesting a similar GVL effect.

Original languageEnglish
Pages (from-to)3110-3118
Number of pages9
JournalBlood
Volume113
Issue number13
DOIs
Publication statusPublished - Mar 26 2009

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Unrelated Donors
Transplants
Hematopoietic Stem Cell Transplantation
HLA Antigens
Stem cells
Grafts
Siblings
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Recurrence
Transplantation (surgical)
Multivariate Analysis
Survival
Cell Transplantation
Proportional Hazards Models
Transplantation
Tissue Donors
Mortality

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation. / Ringdén, Olle; Pavletic, Steven Z.; Anasetti, Claudio; Barrett, A. John; Wang, Tao; Wang, Dan; Antin, Joseph H.; Di Bartolomeo, Paolo; Bolwell, Brian J.; Bredeson, Christopher; Cairo, Mitchell S.; Gale, Robert P.; Gupta, Vikas; Hahn, Theresa; Hale, Gregory A.; Halter, Jorg; Jagasia, Madan; Litzow, Mark R.; Locatelli, Franco; Marks, David I.; McCarthy, Philip L.; Cowan, Morton J.; Petersdorf, Effie W.; Russell, James A.; Schiller, Gary J.; Schouten, Harry; Spellman, Stephen; Verdonck, Leo F.; Wingard, John R.; Horowitz, Mary M.; Arora, Mukta.

In: Blood, Vol. 113, No. 13, 26.03.2009, p. 3110-3118.

Research output: Contribution to journalArticle

Ringdén, O, Pavletic, SZ, Anasetti, C, Barrett, AJ, Wang, T, Wang, D, Antin, JH, Di Bartolomeo, P, Bolwell, BJ, Bredeson, C, Cairo, MS, Gale, RP, Gupta, V, Hahn, T, Hale, GA, Halter, J, Jagasia, M, Litzow, MR, Locatelli, F, Marks, DI, McCarthy, PL, Cowan, MJ, Petersdorf, EW, Russell, JA, Schiller, GJ, Schouten, H, Spellman, S, Verdonck, LF, Wingard, JR, Horowitz, MM & Arora, M 2009, 'The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation', Blood, vol. 113, no. 13, pp. 3110-3118. https://doi.org/10.1182/blood-2008-07-163212
Ringdén, Olle ; Pavletic, Steven Z. ; Anasetti, Claudio ; Barrett, A. John ; Wang, Tao ; Wang, Dan ; Antin, Joseph H. ; Di Bartolomeo, Paolo ; Bolwell, Brian J. ; Bredeson, Christopher ; Cairo, Mitchell S. ; Gale, Robert P. ; Gupta, Vikas ; Hahn, Theresa ; Hale, Gregory A. ; Halter, Jorg ; Jagasia, Madan ; Litzow, Mark R. ; Locatelli, Franco ; Marks, David I. ; McCarthy, Philip L. ; Cowan, Morton J. ; Petersdorf, Effie W. ; Russell, James A. ; Schiller, Gary J. ; Schouten, Harry ; Spellman, Stephen ; Verdonck, Leo F. ; Wingard, John R. ; Horowitz, Mary M. ; Arora, Mukta. / The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation. In: Blood. 2009 ; Vol. 113, No. 13. pp. 3110-3118.
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AU - Ringdén, Olle

AU - Pavletic, Steven Z.

AU - Anasetti, Claudio

AU - Barrett, A. John

AU - Wang, Tao

AU - Wang, Dan

AU - Antin, Joseph H.

AU - Di Bartolomeo, Paolo

AU - Bolwell, Brian J.

AU - Bredeson, Christopher

AU - Cairo, Mitchell S.

AU - Gale, Robert P.

AU - Gupta, Vikas

AU - Hahn, Theresa

AU - Hale, Gregory A.

AU - Halter, Jorg

AU - Jagasia, Madan

AU - Litzow, Mark R.

AU - Locatelli, Franco

AU - Marks, David I.

AU - McCarthy, Philip L.

AU - Cowan, Morton J.

AU - Petersdorf, Effie W.

AU - Russell, James A.

AU - Schiller, Gary J.

AU - Schouten, Harry

AU - Spellman, Stephen

AU - Verdonck, Leo F.

AU - Wingard, John R.

AU - Horowitz, Mary M.

AU - Arora, Mukta

PY - 2009/3/26

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