The growing diversity and spectrum of action of myeloid-derived suppressor cells

Research output: Contribution to journalArticle

Abstract

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of myelomonocytic cells endowed with suppressive activity. MDSC expand and acquire suppressive functions in chronic inflammatory conditions, in particular in neoplastic disorders. As exemplified in two reports in this issue of the European Journal of Immunology, progress has been made in defining MDSC-inducing signals, MDSC phenotypic diversity and spectrum of action. These recent results provide a basis to better define the relationship of MDSC with the adaptive immune responses of mononuclear phagocytes and neutrophils and to exploit their function in a therapeutic setting.

Original languageEnglish
Pages (from-to)3317-3320
Number of pages4
JournalEuropean Journal of Immunology
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Macrophages
  • Myeloid-derived suppressor cells
  • Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The growing diversity and spectrum of action of myeloid-derived suppressor cells'. Together they form a unique fingerprint.

  • Cite this