The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities

Mohamed Maghnie, Valeria Spica-Russotto, Marco Cappa, Michele Autelli, Carmine Tinelli, Patrizia Civolani, Romano Deghenghi, Francesca Severi, Sandro Loche

Research output: Contribution to journalArticle

Abstract

We evaluated the GH-releasing effect of hexarelin (Hex; 2 μg/kg, iv) and GHRH (1 μg/kg, iv) in 18 patients (11 males and 7 females, aged 2.5- 20.4 yr) with GH deficiency (GHD) whose hypothalamic pituitary abnormalities had been previously characterized by dynamic magnetic resonance imaging (MRI). Ten patients had isolated GHD, and 8 had multiple pituitary hormone deficiency. All patients were receiving appropriate hormone replacement therapy. Twenty-four prepubertal short normal children (11 boys and 13 girls, aged 5.9-13 yr, body weight within ±10% of ideal weight) served as controls. MRI studies revealed an ectopic posterior pituitary at the infundibular recess in all patients. A residual vascular component of the pituitary stalk was visualized in 8 patients with isolated GHD (group 1), whereas MRI showed the absence of the pituitary stalk (vascular and neural components) in the remaining 10 patients (group 2), of whom 8 had multiple pituitary hormone deficiency and 2 had isolated GHD. In the short normal children, the mean peak GH response to GHRH (24.8 ± 4.4 μg/L) was significantly lower than that observed after Hex treatment (48.1 ± 4.9 μg/L; P <0.0001). In the GHD patients of group 2, the mean peak GH responses to GHRH (1.4 ± 0.3 μg/L) and Hex (0.9 ± 0.3 μg/L) were similar and markedly low. In the patients of group 1, the GH responses to GHRH (8.7 ± 1.3 μm/L) and Hex (7.0 ± 1.3 μg/L) were also similar, but were significantly higher that those observed in group 2 (P <0.0001). In the whole group of patients, a significant correlation was found between the GH peaks after Hex and those after GHRH (r = 0.746; P <0.0001). In this study we have confirmed that the integrity of the hypothalamic pituitary connections is essential for Hex to express its full GH-releasing activity and that Hex is able to stimulate GH secretion in patients with GHD but with a residual vascular component of the pituitary stalk.

Original languageEnglish
Pages (from-to)3886-3889
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number11
Publication statusPublished - 1998

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Magnetic resonance
Growth Hormone
Pituitary Hormones
Imaging techniques
Pituitary Dwarfism
Pituitary Gland
Blood Vessels
Hormones
Magnetic Resonance Imaging
hexarelin
Hormone Replacement Therapy
Body Weight
Weights and Measures

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities. / Maghnie, Mohamed; Spica-Russotto, Valeria; Cappa, Marco; Autelli, Michele; Tinelli, Carmine; Civolani, Patrizia; Deghenghi, Romano; Severi, Francesca; Loche, Sandro.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 11, 1998, p. 3886-3889.

Research output: Contribution to journalArticle

Maghnie, M, Spica-Russotto, V, Cappa, M, Autelli, M, Tinelli, C, Civolani, P, Deghenghi, R, Severi, F & Loche, S 1998, 'The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities', Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 11, pp. 3886-3889.
Maghnie, Mohamed ; Spica-Russotto, Valeria ; Cappa, Marco ; Autelli, Michele ; Tinelli, Carmine ; Civolani, Patrizia ; Deghenghi, Romano ; Severi, Francesca ; Loche, Sandro. / The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 11. pp. 3886-3889.
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AU - Spica-Russotto, Valeria

AU - Cappa, Marco

AU - Autelli, Michele

AU - Tinelli, Carmine

AU - Civolani, Patrizia

AU - Deghenghi, Romano

AU - Severi, Francesca

AU - Loche, Sandro

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N2 - We evaluated the GH-releasing effect of hexarelin (Hex; 2 μg/kg, iv) and GHRH (1 μg/kg, iv) in 18 patients (11 males and 7 females, aged 2.5- 20.4 yr) with GH deficiency (GHD) whose hypothalamic pituitary abnormalities had been previously characterized by dynamic magnetic resonance imaging (MRI). Ten patients had isolated GHD, and 8 had multiple pituitary hormone deficiency. All patients were receiving appropriate hormone replacement therapy. Twenty-four prepubertal short normal children (11 boys and 13 girls, aged 5.9-13 yr, body weight within ±10% of ideal weight) served as controls. MRI studies revealed an ectopic posterior pituitary at the infundibular recess in all patients. A residual vascular component of the pituitary stalk was visualized in 8 patients with isolated GHD (group 1), whereas MRI showed the absence of the pituitary stalk (vascular and neural components) in the remaining 10 patients (group 2), of whom 8 had multiple pituitary hormone deficiency and 2 had isolated GHD. In the short normal children, the mean peak GH response to GHRH (24.8 ± 4.4 μg/L) was significantly lower than that observed after Hex treatment (48.1 ± 4.9 μg/L; P <0.0001). In the GHD patients of group 2, the mean peak GH responses to GHRH (1.4 ± 0.3 μg/L) and Hex (0.9 ± 0.3 μg/L) were similar and markedly low. In the patients of group 1, the GH responses to GHRH (8.7 ± 1.3 μm/L) and Hex (7.0 ± 1.3 μg/L) were also similar, but were significantly higher that those observed in group 2 (P <0.0001). In the whole group of patients, a significant correlation was found between the GH peaks after Hex and those after GHRH (r = 0.746; P <0.0001). In this study we have confirmed that the integrity of the hypothalamic pituitary connections is essential for Hex to express its full GH-releasing activity and that Hex is able to stimulate GH secretion in patients with GHD but with a residual vascular component of the pituitary stalk.

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