The gut-brain axis

Interactions between enteric microbiota, central and enteric nervous systems

Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, Carola Severi

Research output: Contribution to journalArticle

339 Citations (Scopus)

Abstract

The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. In this review we summarize the available evidence supporting the existence of these interactions, as well as the possible pathophysiological mechanisms involved. Most of the data have been acquired using technical strategies consisting in germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of microbiota-GBA interactions comes from the association of dysbiosis with central nervous disorders (i.e. autism, anxiety-depressive behaviors) and functional gastrointestinal disorders. In particular, irritable bowel syndrome can be considered an example of the disruption of these complex relationships, and a better understanding of these alterations might provide new targeted therapies.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalAnnals of Gastroenterology
Volume28
Issue number2
Publication statusPublished - 2015

Fingerprint

Enteric Nervous System
Microbiota
Central Nervous System
Brain
Dysbiosis
Irritable Bowel Syndrome
Gastrointestinal Diseases
Probiotics
Autistic Disorder
Anxiety
Animal Models
Communication
Gastrointestinal Microbiome
Anti-Bacterial Agents
Infection
Research

Keywords

  • Central nervous system
  • Enteric microbiota
  • Enteric nervous system
  • Gut-brain axis
  • Irritable bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The gut-brain axis : Interactions between enteric microbiota, central and enteric nervous systems. / Carabotti, Marilia; Scirocco, Annunziata; Maselli, Maria Antonietta; Severi, Carola.

In: Annals of Gastroenterology, Vol. 28, No. 2, 2015, p. 203-209.

Research output: Contribution to journalArticle

Carabotti, Marilia ; Scirocco, Annunziata ; Maselli, Maria Antonietta ; Severi, Carola. / The gut-brain axis : Interactions between enteric microbiota, central and enteric nervous systems. In: Annals of Gastroenterology. 2015 ; Vol. 28, No. 2. pp. 203-209.
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