Abstract
The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. In this review we summarize the available evidence supporting the existence of these interactions, as well as the possible pathophysiological mechanisms involved. Most of the data have been acquired using technical strategies consisting in germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of microbiota-GBA interactions comes from the association of dysbiosis with central nervous disorders (i.e. autism, anxiety-depressive behaviors) and functional gastrointestinal disorders. In particular, irritable bowel syndrome can be considered an example of the disruption of these complex relationships, and a better understanding of these alterations might provide new targeted therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 203-209 |
| Number of pages | 7 |
| Journal | Annals of Gastroenterology |
| Volume | 28 |
| Issue number | 2 |
| Publication status | Published - 2015 |
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Keywords
- Central nervous system
- Enteric microbiota
- Enteric nervous system
- Gut-brain axis
- Irritable bowel syndrome
ASJC Scopus subject areas
- Gastroenterology
Cite this
The gut-brain axis : Interactions between enteric microbiota, central and enteric nervous systems. / Carabotti, Marilia; Scirocco, Annunziata; Maselli, Maria Antonietta; Severi, Carola.
In: Annals of Gastroenterology, Vol. 28, No. 2, 2015, p. 203-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The gut-brain axis
T2 - Interactions between enteric microbiota, central and enteric nervous systems
AU - Carabotti, Marilia
AU - Scirocco, Annunziata
AU - Maselli, Maria Antonietta
AU - Severi, Carola
PY - 2015
Y1 - 2015
N2 - The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. In this review we summarize the available evidence supporting the existence of these interactions, as well as the possible pathophysiological mechanisms involved. Most of the data have been acquired using technical strategies consisting in germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of microbiota-GBA interactions comes from the association of dysbiosis with central nervous disorders (i.e. autism, anxiety-depressive behaviors) and functional gastrointestinal disorders. In particular, irritable bowel syndrome can be considered an example of the disruption of these complex relationships, and a better understanding of these alterations might provide new targeted therapies.
AB - The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. In this review we summarize the available evidence supporting the existence of these interactions, as well as the possible pathophysiological mechanisms involved. Most of the data have been acquired using technical strategies consisting in germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of microbiota-GBA interactions comes from the association of dysbiosis with central nervous disorders (i.e. autism, anxiety-depressive behaviors) and functional gastrointestinal disorders. In particular, irritable bowel syndrome can be considered an example of the disruption of these complex relationships, and a better understanding of these alterations might provide new targeted therapies.
KW - Central nervous system
KW - Enteric microbiota
KW - Enteric nervous system
KW - Gut-brain axis
KW - Irritable bowel syndrome
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M3 - Article
VL - 28
SP - 203
EP - 209
JO - Annals of Gastroenterology
JF - Annals of Gastroenterology
SN - 1108-7471
IS - 2
ER -