The Gut Immune Barrier and the Blood-Brain Barrier

Are They So Different?

Richard Daneman, Maria Rescigno

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

In order to protect itself from a diverse set of environmental pathogens and toxins, the body has developed a number of barrier mechanisms to limit the entry of potential hazards. Here, we compare two such barriers: the gut immune barrier, which is the primary barrier against pathogens and toxins ingested in food, and the blood-brain barrier, which protects the central nervous system from pathogens and toxins in the blood. Although each barrier provides defense in very different environments, there are many similarities in their mechanisms of action. In both cases, there is a physical barrier formed by a cellular layer that tightly regulates the movement of ions, molecules, and cells between two tissue spaces. These barrier cells interact with different cell types, which dynamically regulate their function, and with a different array of immune cells that survey the physical barrier and provide innate and adaptive immunity.

Original languageEnglish
Pages (from-to)722-735
Number of pages14
JournalImmunity
Volume31
Issue number5
DOIs
Publication statusPublished - Nov 20 2009

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Blood-Brain Barrier
Architectural Accessibility
Adaptive Immunity
Innate Immunity
Central Nervous System
Ions
Food

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

The Gut Immune Barrier and the Blood-Brain Barrier : Are They So Different? / Daneman, Richard; Rescigno, Maria.

In: Immunity, Vol. 31, No. 5, 20.11.2009, p. 722-735.

Research output: Contribution to journalArticle

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