The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials

Giovanni Schepici, Serena Silvestro, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalReview article

Abstract

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and degenerative disease that affects the central nervous system. A recent study showed that interaction between the immune system and the gut microbiota plays a crucial role in the development of MS. This review reports the clinical studies carried out in recent years that aimed to evaluate the composition of the microbiota in patients with relapsing–remitting MS (RR-MS). We also report what is available in the literature regarding the effectiveness of fecal microbiota transplantation and the role of the diet in restoring the intestinal bacterial population. Studies report that patients with RR-MS have a microbiota that, compared with healthy controls, has higher amounts of Pedobacteria, Flavobacterium, Pseudomonas, Mycoplana, Acinetobacter, Eggerthella, Dorea, Blautia, Streptococcus and Akkermansia. In contrast, MS patients have a microbiota with impoverished microbial populations of Prevotella, Bacteroides, Parabacteroides, Haemophilus, Sutterella, Adlercreutzia, Coprobacillus, Lactobacillus, Clostridium, Anaerostipes and Faecalibacterium. In conclusion, the restoration of the microbial population in patients with RR-MS appears to reduce inflammatory events and the reactivation of the immune system.

Original languageEnglish
Pages (from-to)1507-1527
Number of pages21
JournalCell Transplantation
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 1 2019

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Keywords

  • diet
  • fecal microbiota transplantation
  • microbiota
  • multiple sclerosis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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