The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Giovanni Delogu; Maurizio Sanguinetti; Brunella Posteraro; Stefano Rocca; Stefania Zanetti; Giovanni Fadda

doi:10.1128/IAI.74.5.3006-3011.2006

The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Giovanni Delogu, Maurizio Sanguinetti, Brunella Posteraro, Stefano Rocca, Stefania Zanetti, Giovanni Fadda

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

Original language	English
Pages (from-to)	3006-3011
Number of pages	6
Journal	Infection and Immunity
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/IAI.74.5.3006-3011.2006
Publication status	Published - May 2006

ASJC Scopus subject areas

Immunology

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The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice. / Delogu, Giovanni; Sanguinetti, Maurizio; Posteraro, Brunella; Rocca, Stefano; Zanetti, Stefania; Fadda, Giovanni.

In: Infection and Immunity, Vol. 74, No. 5, 05.2006, p. 3006-3011.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.",

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