The heart and shell. Anatomical and genetic similarities

Paolo Versacci, Maria Cristina Digilio, Marco Oliverio, Bruno Dallapiccola, Bruno Marino

Research output: Contribution to journalArticlepeer-review


Phenotypic resemblance does exist between normal and abnormal spiralization of great arteries in vertebrates and the spiral patterns of snail shells. The conserved Nodal gene is involved in the morphogenetic mechanism of these spiralizations in the great arteries of vertebrates and snail shells. These observationswiden the phylogenetic development horizon in humans20,21 and allowus to look at the harmonic heart anatomy from a new evolutionary perspective.

Original languageEnglish
Pages (from-to)647-649
Number of pages3
JournalAmerican Heart Journal
Issue number4
Publication statusPublished - Apr 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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