Il cuore nelle adolescenti anoressiche

Translated title of the contribution: The heart in anorexic teenage girls

Massimo Silvetti, Marco Magnani, Antonella Santilli, Gaetano Di Liso, Antonella Diamanti, Emanuela Pompei, Manuela Gambarara, Francesco Montecchi, Pietro Ragonese

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND. Anorexia nervosa (AN) is often associated with cardiac changes, such as thinning of the left ventricle (LV), reduction of LV mass, abnormalities of mitral valve function and systolic dysfunction. Some authors have reported QT interval prolongation and sudden death in these patients. METHODS. We studied 23 adolescent females, aged 14.7 ± 2 years (mean ± SD), with AN. Serum electrolytes, proteins and albumin were measured in all patients. Electrocardiogram, Doppler-echocardiogram and chest X-rays were also performed on the same day. Eighteen patients were also examined via indirect calorimetry (difference from basal metabolic rate) and 21 underwent dosage of thyroid hormones. RESULTS. The patients, who were of normal height (159 ± 7.4 cm), were underweight (36 ± 4.8 kg) and had a body mass index (BMI) of less than 19 (14.2 ± 1.3). Serum electrolytes, proteins, albumin and chest X-rays were substantially normal in all patients; 74% of them showed reduction of FT3. The calorimetry was reduced (-27.1 ± 10.6%) with the exception of one patient. Resting heart rate was 58 ± 12 bpm. We found normal values for PR, QRS, QT (0.41 ± 0.03 s( 1/4 )) and QTc intervals (0.40 ± 0.03 s( 1/4 )) and QT dispersion (40.9 ± 14.1 ms). Echocardiography showed e reduction in the dimensions of the interventricular septum (52% of patients), LV free wall (61%), left atrium (31%) and LV mass (61%). Fractional shortening was normal in all but one patient. In 61% of cases, there was mild or moderate pericardial effusion that was clinically silent and inversely related to BMI (r= -0.38, p 0.08, ns), to calorimetry (r = -0.56, p <0.0055), to FT3 (r = -0.53, p <0.05) and to sodium concentrations (r = - 0.43, p 0.04). CONCLUSIONS. Teen-agers with AN often show e reduction in LV thickness and mass, as well as clinically silent pericardial effusion that is inversely related to BMI, calorimetry, FT3 and sodium serum concentrations. We did not find any prolongation of QTc interval or of QT dispersion.

Original languageItalian
Pages (from-to)131-139
Number of pages9
JournalGiornale Italiano di Cardiologia
Volume28
Issue number2
Publication statusPublished - Feb 1998

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Heart Ventricles
Calorimetry
Anorexia Nervosa
Body Mass Index
Pericardial Effusion
Electrolytes
Blood Proteins
Thorax
Sodium
X-Rays
Basal Metabolism
Indirect Calorimetry
Thinness
Sudden Death
Heart Atria
Mitral Valve
Thyroid Hormones
Serum Albumin
Echocardiography
Albumins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Silvetti, M., Magnani, M., Santilli, A., Di Liso, G., Diamanti, A., Pompei, E., ... Ragonese, P. (1998). Il cuore nelle adolescenti anoressiche. Giornale Italiano di Cardiologia, 28(2), 131-139.

Il cuore nelle adolescenti anoressiche. / Silvetti, Massimo; Magnani, Marco; Santilli, Antonella; Di Liso, Gaetano; Diamanti, Antonella; Pompei, Emanuela; Gambarara, Manuela; Montecchi, Francesco; Ragonese, Pietro.

In: Giornale Italiano di Cardiologia, Vol. 28, No. 2, 02.1998, p. 131-139.

Research output: Contribution to journalArticle

Silvetti, M, Magnani, M, Santilli, A, Di Liso, G, Diamanti, A, Pompei, E, Gambarara, M, Montecchi, F & Ragonese, P 1998, 'Il cuore nelle adolescenti anoressiche', Giornale Italiano di Cardiologia, vol. 28, no. 2, pp. 131-139.
Silvetti M, Magnani M, Santilli A, Di Liso G, Diamanti A, Pompei E et al. Il cuore nelle adolescenti anoressiche. Giornale Italiano di Cardiologia. 1998 Feb;28(2):131-139.
Silvetti, Massimo ; Magnani, Marco ; Santilli, Antonella ; Di Liso, Gaetano ; Diamanti, Antonella ; Pompei, Emanuela ; Gambarara, Manuela ; Montecchi, Francesco ; Ragonese, Pietro. / Il cuore nelle adolescenti anoressiche. In: Giornale Italiano di Cardiologia. 1998 ; Vol. 28, No. 2. pp. 131-139.
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AU - Gambarara, Manuela

AU - Montecchi, Francesco

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N2 - BACKGROUND. Anorexia nervosa (AN) is often associated with cardiac changes, such as thinning of the left ventricle (LV), reduction of LV mass, abnormalities of mitral valve function and systolic dysfunction. Some authors have reported QT interval prolongation and sudden death in these patients. METHODS. We studied 23 adolescent females, aged 14.7 ± 2 years (mean ± SD), with AN. Serum electrolytes, proteins and albumin were measured in all patients. Electrocardiogram, Doppler-echocardiogram and chest X-rays were also performed on the same day. Eighteen patients were also examined via indirect calorimetry (difference from basal metabolic rate) and 21 underwent dosage of thyroid hormones. RESULTS. The patients, who were of normal height (159 ± 7.4 cm), were underweight (36 ± 4.8 kg) and had a body mass index (BMI) of less than 19 (14.2 ± 1.3). Serum electrolytes, proteins, albumin and chest X-rays were substantially normal in all patients; 74% of them showed reduction of FT3. The calorimetry was reduced (-27.1 ± 10.6%) with the exception of one patient. Resting heart rate was 58 ± 12 bpm. We found normal values for PR, QRS, QT (0.41 ± 0.03 s( 1/4 )) and QTc intervals (0.40 ± 0.03 s( 1/4 )) and QT dispersion (40.9 ± 14.1 ms). Echocardiography showed e reduction in the dimensions of the interventricular septum (52% of patients), LV free wall (61%), left atrium (31%) and LV mass (61%). Fractional shortening was normal in all but one patient. In 61% of cases, there was mild or moderate pericardial effusion that was clinically silent and inversely related to BMI (r= -0.38, p 0.08, ns), to calorimetry (r = -0.56, p <0.0055), to FT3 (r = -0.53, p <0.05) and to sodium concentrations (r = - 0.43, p 0.04). CONCLUSIONS. Teen-agers with AN often show e reduction in LV thickness and mass, as well as clinically silent pericardial effusion that is inversely related to BMI, calorimetry, FT3 and sodium serum concentrations. We did not find any prolongation of QTc interval or of QT dispersion.

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