Abstract
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 10-21 |
| Number of pages | 12 |
| Journal | Cancer Cell |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 8 2008 |
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ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Oncology
Cite this
The HECT Family of E3 Ubiquitin Ligases : Multiple Players in Cancer Development. / Bernassola, Francesca; Karin, Michael; Ciechanover, Aaron; Melino, Gerry.
In: Cancer Cell, Vol. 14, No. 1, 08.07.2008, p. 10-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The HECT Family of E3 Ubiquitin Ligases
T2 - Multiple Players in Cancer Development
AU - Bernassola, Francesca
AU - Karin, Michael
AU - Ciechanover, Aaron
AU - Melino, Gerry
PY - 2008/7/8
Y1 - 2008/7/8
N2 - The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
AB - The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
UR - http://www.scopus.com/inward/record.url?scp=45849153870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849153870&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2008.06.001
DO - 10.1016/j.ccr.2008.06.001
M3 - Article
C2 - 18598940
AN - SCOPUS:45849153870
VL - 14
SP - 10
EP - 21
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 1
ER -