The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

Francesca Bernassola, Michael Karin, Aaron Ciechanover, Gerry Melino

Research output: Contribution to journalArticlepeer-review

Abstract

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalCancer Cell
Volume14
Issue number1
DOIs
Publication statusPublished - Jul 8 2008

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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