The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: Study design and baseline factors

Esther M. Hoffmann, Stefano Miglior, Thierry Zeyen, Valter Torri, Eliana Rulli, Shakhsanam Aliyeva, Irene Floriani, José Cunha-Vaz, Norbert Pfeiffer

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the study design and baseline factors of the Heidelberg Retina Tomograph ancillary study within the EGPS. Furthermore, to examine the relationship between HRT optic disc topographic measurements and baseline demographic and ocular factors. Methods: Four hundred and eighty-nine ocular hypertensive participants were included. Each participant completed HRT imaging at least annually. The associations between HRT measurements and IOP, central corneal thickness (CCT), baseline photographic estimates of vertical CDR ratio (CDR), asymmetry between the two eyes in CDR ratio and baseline visual field indices were assessed using regression analysis. Results: Associations between HRT measurements and vertical CDR by photographs were found for almost all stereometric optic disc parameters in both univariate and multivariate analysis. The strongest association was found between vertical CDR measurements and disc, cup and rim area; cup and rim volume, CDR area, linear CDR, mean and maximum cup depth and cup shape measure (all p <0.0001). In multivariate analysis, pattern standard deviation (PSD) and HRT disc area had significant associations with several HRT optic disc measurements. Furthermore, CCT was significantly associated with reference height and the glaucoma probability score (GPS, outside normal limits). Conclusions: The EGPS is the first multicentre, placebo-controlled randomized clinical trial to use HRT for monitoring optic disc changes in participants with ocular hypertension. We found strong associations between stereophotographic vertical CDR estimates, HRT disc area, PSD and several HRT parameters. We found, furthermore, that the parameters reference height and GPS were significantly related to central corneal thickness.

Original languageEnglish
JournalActa Ophthalmologica
Issue number8
Publication statusPublished - Dec 2013


  • central corneal thickness
  • glaucoma
  • HRT parameter
  • intraocular pressure
  • ocular hypertension
  • pattern standard deviation
  • scanning laser ophthalmoscopy

ASJC Scopus subject areas

  • Ophthalmology


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