The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease

M. Sampietro, L. Caputo, A. Casatta, M. Meregalli, A. Pellagatti, J. Tagliabue, G. Annoni, C. Vergani

Research output: Contribution to journalArticlepeer-review

Abstract

NEUROBIOL AGING. In the present study we analysed the genotype of HFE, the gene involved in hemochromatosis, in 107 patients with sporadic late-onset AD and in 99 age-matched non-demented controls. We observed that patients carrying the mutant HFE-H63D allele had a mean age at onset of 71.7 ± 6.0 years versus 76.6 ± 5.8 years of those who were homozygous for the wild-type allele (p = 0.001). The frequency of the HFE-H63D mutation was highest (0.22) in the patients aged

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalNeurobiology of Aging
Volume22
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Alzheimer's disease
  • APOE
  • Dementia
  • Disease onset
  • Hemochromatosis
  • Iron
  • Mutation

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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