EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA

Translated title of the contribution: The hemodynamic effects of reproterol in patients with chronic obstructive lung disease

D. Bonaduce, N. Ferrara, V. Canonico, M. Cocozza, M. Petretta, E. Romano, F. Rengo

Research output: Contribution to journalArticle

Abstract

Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomolecular combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; systolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until the 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results show that reproterol has a benefical effect on pulmonary hemodynamics in COLD.

Original languageItalian
Pages (from-to)1467-1471
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume11
Issue number10
Publication statusPublished - 1981

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reproterol
Chronic Obstructive Pulmonary Disease
Hemodynamics
Catecholamines
Lung
Blood Pressure
Pulmonary Wedge Pressure
Phosphoric Diester Hydrolases
Theophylline
Intravenous Administration
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bonaduce, D., Ferrara, N., Canonico, V., Cocozza, M., Petretta, M., Romano, E., & Rengo, F. (1981). EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. Giornale Italiano di Cardiologia, 11(10), 1467-1471.

EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. / Bonaduce, D.; Ferrara, N.; Canonico, V.; Cocozza, M.; Petretta, M.; Romano, E.; Rengo, F.

In: Giornale Italiano di Cardiologia, Vol. 11, No. 10, 1981, p. 1467-1471.

Research output: Contribution to journalArticle

Bonaduce, D, Ferrara, N, Canonico, V, Cocozza, M, Petretta, M, Romano, E & Rengo, F 1981, 'EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA', Giornale Italiano di Cardiologia, vol. 11, no. 10, pp. 1467-1471.
Bonaduce D, Ferrara N, Canonico V, Cocozza M, Petretta M, Romano E et al. EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. Giornale Italiano di Cardiologia. 1981;11(10):1467-1471.
Bonaduce, D. ; Ferrara, N. ; Canonico, V. ; Cocozza, M. ; Petretta, M. ; Romano, E. ; Rengo, F. / EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. In: Giornale Italiano di Cardiologia. 1981 ; Vol. 11, No. 10. pp. 1467-1471.
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