Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomolecular combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; systolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until the 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results show that reproterol has a benefical effect on pulmonary hemodynamics in COLD.
|Translated title of the contribution||The hemodynamic effects of reproterol in patients with chronic obstructive lung disease|
|Number of pages||5|
|Journal||Giornale Italiano di Cardiologia|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine