EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA

Translated title of the contribution: The hemodynamic effects of reproterol in patients with chronic obstructive lung disease

D. Bonaduce, N. Ferrara, V. Canonico, M. Cocozza, M. Petretta, E. Romano, F. Rengo

Research output: Contribution to journalArticle

Abstract

Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomolecular combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; systolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until the 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results show that reproterol has a benefical effect on pulmonary hemodynamics in COLD.

Translated title of the contributionThe hemodynamic effects of reproterol in patients with chronic obstructive lung disease
Original languageItalian
Pages (from-to)1467-1471
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume11
Issue number10
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Bonaduce, D., Ferrara, N., Canonico, V., Cocozza, M., Petretta, M., Romano, E., & Rengo, F. (1981). EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. Giornale Italiano di Cardiologia, 11(10), 1467-1471.