The heterogeneity of amyotrophic lateral sclerosis: A possible explanation of treatment failure

Ettore Beghi, Tiziana Mennini, Caterina Bendotti, Paolo Bigini, Giancarlo Logroscino, Adriano Chiò, Orla Hardiman, Douglas Mitchell, Robert Swingler, Bryan J. Traynor, Ammar Al-Chalabi

Research output: Contribution to journalArticlepeer-review


Amyotrophic lateral sclerosis (ALS) is a severe clinical condition characterized by upper and lower motor neuron degeneration for which there is no truly effective treatment. The absence of an effective treatment can be explained in part by the complex and heterogeneous genetic, biochemical, and clinical features of ALS. While ALS accounts for the majority of the motor neuron diseases, the recognition of disease variants and mimic syndromes may lead to further insights into possible causes for the generality of ALS. From a biochemical perspective, the process of motor neuron degeneration is complex and the multifactorial influences and potential biomarkers of ALS have never been assessed in the light of the clinical heterogeneity of ALS. Several genes and environmental influences have been suggested as possible risk factors of ALS. A better understanding of interactions between these risk factors, potential biomarkers and heterogeneous clinical features may lead to more clearly defined pathological profiles among individuals or groups of ALS patients and in turn lead to more focused therapeutic trials.

Original languageEnglish
Pages (from-to)3185-3200
Number of pages16
JournalCurrent Medicinal Chemistry
Issue number30
Publication statusPublished - Dec 2007


  • Amyotrophic lateral sclerosis
  • Biochemistry
  • Epidemiology
  • Genetics
  • Heterogeneity
  • Motor neuron disease

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology


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