The HGF receptor family: Unconventional signal transducers for invasive cell growth

Paolo M. Comoglio, Carla Boccaccio

Research output: Contribution to journalArticle

Abstract

The HGF receptor family includes tyrosine kinases encoded by three oncogenes: MET, SEA and RON. The members of this gene family share a unique functional feature: they mediate cell dissociation and motility ('scattering') in physiological conditions, and invasiveness in their activated versions. The Met, Ron and Sea receptors display a distinctive signal transduction behaviour. Unlike conventional growth factor receptors, their cytoplasmic tails contain a multifunctional docking site. Upon autophosphorylation, this sequence simultaneously binds and activates multiple SH2-containing transducers, including Ras and PI 3-kinase. A deregulated activation of this 'supersite' triggers a dramatic pleiotropic signal which is responsible for invasive cell growth.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalGenes to Cells
Volume1
Issue number4
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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