The hidden (and lazy) TCR

Research output: Contribution to journalArticlepeer-review


In this issue of Blood, Burns and colleagues analyzed samples from 18 patients with melanoma, treated with T lymphocytes gene-modified to express a tumor-specific TCR. Results show persistence of transduced cells, but early shutdown of TCR gene expression. Transgene down-regulation was not caused by epigenetic silencing and could be reversed by T-cell activation.

Original languageEnglish
Pages (from-to)2855-2856
Number of pages2
Issue number14
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology


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