Abstract
In this issue of Blood, Burns and colleagues analyzed samples from 18 patients with melanoma, treated with T lymphocytes gene-modified to express a tumor-specific TCR. Results show persistence of transduced cells, but early shutdown of TCR gene expression. Transgene down-regulation was not caused by epigenetic silencing and could be reversed by T-cell activation.
Original language | English |
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Pages (from-to) | 2855-2856 |
Number of pages | 2 |
Journal | Blood |
Volume | 114 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2009 |
ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology