The hidden hypothesis

A disseminated tuberculosis case

Sergio Foresti, Maria Rita Perego, Manuela Carugati, Anna Casati, Cristina Malafronte, Marco Manzoni, Raffaele Badolato, Andrea Gori, Felice Achilli

Research output: Contribution to journalArticle

Abstract

Case presentation: 77-year-old former smoker admitted because of fatigue and abdominal distention. Past medical history positive for two previous hospitalizations for pericardial and pleural effusions (no diagnosis achieved). At admission erythrocyte sedimentation rate was 122 mm per hour. Baseline investigations revealed ascitic, pleural and pericardial effusion. Effusions were tapped: neoplastic cells and acid-fast bacilli (AFB) were not identified, aerobic and mycobacterial culture resulted negative. QuantiFERON TB-Gold test was negative. Total body PET-CT and autoimmunity panel were negative. A neoplastic process was considered the most likely explanation. Before signing off the patient to comfort care, a reassessment was performed and an exposure to tuberculosis during childhood was documented. Because of constrictive pericarditis, pericardiectomy was performed: histologic examination showed chronic pericardial inflammation without granulomas, but Ziehl-Neelsen stain identified AFB and PCR was positive for Mycobacterium tuberculosis complex. Patient was started on anti-TB therapy with resolution of the effusions in the following months. Genes associated with defects in innate immunity were sequences and dentritic cells were studied, but no alterations were identified. Discussion: A Bayesian approach to clinical decision making should be recommended. Interpretation of diagnostic tests should take into account the imperfect diagnostic performance of the majority of these tests. Further studies to investigate genetic susceptibility to tuberculosis are needed.

Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume85
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Pericardial Effusion
Pleural Effusion
Bacillus
Tuberculosis
Pericardiectomy
Constrictive Pericarditis
Neoplastic Processes
Acids
Bayes Theorem
Blood Sedimentation
Genetic Predisposition to Disease
Granuloma
Autoimmunity
Mycobacterium tuberculosis
Routine Diagnostic Tests
Innate Immunity
Gold
Fatigue
Hospitalization
Coloring Agents

Keywords

  • Bayes
  • Diagnostic performance
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

The hidden hypothesis : A disseminated tuberculosis case. / Foresti, Sergio; Perego, Maria Rita; Carugati, Manuela; Casati, Anna; Malafronte, Cristina; Manzoni, Marco; Badolato, Raffaele; Gori, Andrea; Achilli, Felice.

In: International Journal of Infectious Diseases, Vol. 85, 01.08.2019, p. 88-91.

Research output: Contribution to journalArticle

Foresti, Sergio ; Perego, Maria Rita ; Carugati, Manuela ; Casati, Anna ; Malafronte, Cristina ; Manzoni, Marco ; Badolato, Raffaele ; Gori, Andrea ; Achilli, Felice. / The hidden hypothesis : A disseminated tuberculosis case. In: International Journal of Infectious Diseases. 2019 ; Vol. 85. pp. 88-91.
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