The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

M. Matz, M.P. Coleman, M. Sant, M.D. Chirlaque, O. Visser, M. Gore, C. Allemani, S. Bouzbid, M. Hamdi-Chérif, Z. Zaidi, E. Bah, R. Swaminathan, S.H. Nortje, D. C.Stefan, M.M. El Mistiri, S. Bayo, B. Malle, S.S. Manraj, R. Sewpaul-Sungkur, A. FabowaleO.J. Ogunbiyi, D. Bradshaw, N.I.M. Somdyala, M. Abdel-Rahman, L. Jaidane, M. Mokni, I. Kumcher, F. Moreno, M.S. González, E.A. Laura, S.B. Espinola, G.H. Calabrano, B. Carballo Quintero, R. Fita, D.A. Garcilazo, P.L. Giacciani, M.C. Diumenjo, W.D. Laspada, M.A. Green, M.F. Lanza, S.G. Ibañez, C.A. Lima, E. Lobo de Oliveira, C. Daniel, C. Scandiuzzi, P.C.F. De Souza, C.D. Melo, K. Del Pino, C. Laporte, M.P. Curado, J.C. de Oliveira, C.L.A. Veneziano, D.B. Veneziano, T.S. Alexandre, A.S. Verdugo, G. Azevedo e Silva, J.C. Galaz, J.A. Moya, D.A. Herrmann, S. Vargas, V.M. Herrera, C.J. Uribe, L.E. Bravo, N.E. Arias-Ortiz, D.M. Jurado, M.C. Yépez, Y.H. Galán, P. Torres, F. Martínez-Reyes, M.L. Pérez-Meza, L. Jaramillo, R. Quinto, P. Cueva, J.G. Yépez, C.R. Torres-Cintrón, G. Tortolero-Luna, R. Alonso, E. Barrios, C. Nikiforuk, L. Shack, A.J. Coldman, R.R. Woods, G. Noonan, D. Turner, E. Kumar, B. Zhang, F.R. McCrate, S. Ryan, H. Hannah, R.A.D. Dewar, M. MacIntyre, A. Lalany, M. Ruta, L. Marrett, D.E. Nishri, C. McClure, K.A. Vriends, C. Bertrand, R. Louchini, K.I. Robb, H. Stuart-Panko, S. Demers, S. Wright, J.T. George, X. Shen, J.T. Brockhouse, D.K. O'Brien, K.C. Ward, L. Almon, J. Bates, R. Rycroft, L. Mueller, C. Phillips, H. Brown, B. Cromartie, A.G. Schwartz, F. Vigneau, J.A. MacKinnon, B. Wohler, A.R. Bayakly, C.A. Clarke, S.L. Glaser, D. West, M.D. Green, B.Y. Hernandez, C.J. Johnson, D. Jozwik, M.E. Charlton, C.F. Lynch, B. Huang, T.C. Tucker, D. Deapen, L. Liu, M.C. Hsieh, X.C. Wu, K. Stern, S.T. Gershman, R.C. Knowlton, J. Alverson, G.E. Copeland, D.B. Rogers, D. Lemons, L.L. Williamson, M. Hood, G.M. Hosain, J.R. Rees, K.S. Pawlish, A. Stroup, C. Key, C. Wiggins, A.R. Kahn, M.J. Schymura, G. Leung, C. Rao, L. Giljahn, B. Warther, A. Pate, M. Patil, S.S. Schubert, J.J. Rubertone, S.J. Slack, J.P. Fulton, D.L. Rousseau, T.A. Janes, S.M. Schwartz, S.W. Bolick, D.M. Hurley, J. Richards, M.A. Whiteside, L.M. Nogueira, K. Herget, C. Sweeney, J. Martin, S. Wang, D.G. Harrelson, M.B. Keitheri Cheteri, S. Farley, A.G. Hudson, R. Borchers, L. Stephenson, J.R. Espinoza, H.K. Weir, B.K. Edwards, N. Wang, L. Yang, J.S. Chen, G.H. Song, X.P. Gu, P. Zhang, H.M. Ge, D.L. Zhao, J.H. Zhang, F.D. Zhu, J.G. Tang, Y. Shen, J. Wang, Q.L. Li, X.P. Yang, J. Dong, W. Li, L.P. Cheng, J.G. Chen, Q.H. Huang, S.Q. Huang, G.P. Guo, K. Wei, W.Q. Chen, H. Zeng, A.V. Demetriou, P. Pavlou, W.K. Mang, K.C. Ngan, A.C. Kataki, M. Krishnatreya, P.A. Jayalekshmi, P. Sebastian, S.D. Sapkota, Y. Verma, A. Nandakumar, E. Suzanna, L. Keinan-Boker, B.G. Silverman, H. Ito, H. Nakagawa, M. Hattori, Y. Kaizaki, H. Sugiyama, M. Utada, K. Katayama, H. Narimatsu, S. Kanemura, T. Koike, I. Miyashiro, M. Yoshii, I. Oki, A. Shibata, T. Matsuda, O. Nimri, A. Ab Manan, N. Bhoo Pathy, O. Chimedsuren, S. Tuvshingerel, A.H.M. Al Khater, H. Al-Eid, K.W. Jung, Y.J. Won, C.J. Chiang, M.S. Lai, K. Suwanrungruang, S. Wiangnon, K. Daoprasert, D. Pongnikorn, S.L. Geater, H. Sriplung, S. Eser, C.I. Yakut, M. Hackl, H. Mühlböck, W. Oberaigner, A.A. Zborovskaya, O.V. Aleinikova, K. Henau, L. Van Eycken, N. Dimitrova, Z. Valerianova, M. Šekerija, M. Zvolský, G. Engholm, H. Storm, K. Innos, M. Mägi, N. Malila, K. Seppä, J. Jégu, M. Velten, E. Cornet, X. Troussard, A.M. Bouvier, J. Faivre, A.V. Guizard, V. Bouvier, G. Launoy, P. Arveux, M. Maynadié, M. Mounier, E. Fournier, A.S. Woronoff, M. Daoulas, J. Clavel, S. Le Guyader-Peyrou, A. Monnereau, B. Trétarre, M. Colonna, A. Cowppli-Bony, F. Molinié, S. Bara, D. Degré, O. Ganry, B. Lapôtre-Ledoux, P. Grosclaude, J. Estève, F. Bray, M. Piñeros, F. Sassi, R. Stabenow, A. Eberle, C. Erb, A. Nennecke, J. Kieschke, E. Sirri, H. Kajueter, K. Emrich, S.R. Zeissig, B. Holleczek, N. Eisemann, A. Katalinic, H. Brenner, R.A. Asquez, V. Kumar, E.J. Ólafsdóttir, L. Tryggvadóttir, H. Comber, P.M. Walsh, H. Sundseth, E. Devigili, G. Mazzoleni, A. Giacomin, F. Bella, M. Castaing, A. Sutera, G. Gola, S. Ferretti, D. Serraino, A. Zucchetto, R. Lillini, M. Vercelli, S. Busco, F. Pannozzo, S. Vitarelli, P. Ricci, C. Pascucci, M. Autelitano, C. Cirilli, M. Federico, M. Fusco, M.F. Vitale, M. Usala, R. Cusimano, W. Mazzucco, M. Michiara, P. Sgargi, M.M. Maule, C. Sacerdote, R. Tumino, E. Di Felice, M. Vicentini, F. Falcini, L. Cremone, M. Budroni, R. Cesaraccio, M.L. Contrino, F. Tisano, A.C. Fanetti, S. Maspero, G. Candela, T. Scuderi, M.A. Gentilini, S. Piffer, S. Rosso, L. Sacchetto, A. Caldarella, F. La Rosa, F. Stracci, P. Contiero, G. Tagliabue, A.P. Dei Tos, M. Zorzi, R. Zanetti, P. Baili, F. Berrino, G. Gatta, R. Capocaccia, R. De Angelis, E. Liepina, A. Maurina, G. Smailyte, D. Agius, N. Calleja, S. Siesling, S. Larønningen, B. Møller, A. Dyzmann-Sroka, M. Trojanowski, S. Góźdż, M. Grądalska-Lampart R.Mężyk, A.U. Radziszewska, J.A. Didkowska, U. Wojciechowska, J. Błaszczyk, K. Kępska, M. Bielska-Lasota, K. Kwiatkowska, G. Forjaz, R.A. Rego, J. Bastos, M.A. Silva, L. Antunes, M.J. Bento, A. Mayer-da-Silva, A. Miranda, D. Coza, A.I. Todescu, M.Y. Valkov, J. Adamcik, C. Safaei Diba, M. Primic-Žakelj, T. Žagar, J. Stare, E. Almar, A. Mateos, J.R. Quirós, J. Bidaurrazaga, N. Larrañaga, J.M. Díaz García, A.I. Marcos, R. Marcos-Gragera, M.L. Vilardell Gil, E. Molina, M.J. Sánchez, P. Franch Sureda, M. RamosMontserrat, C. Navarro, E.E. Ardanaz, C.C. Moreno-Iribas, R. Fernández-Delgado, R. Peris-Bonet, J. Galceran, S. Khan, M. Lambe, B. Camey, C. Bouchardy, M. Usel, S.M. Ess, C. Herrmann, J.L. Bulliard, M. Maspoli-Conconi, H. Frick, C.E. Kuehni, M. Schindler, A. Bordoni, A. Spitale, A. Chiolero, I. Konzelmann, S.I. Dehler, K.L. Matthes, J. Rashbass, C. Stiller, D. Fitzpatrick, A. Gavin, F. Bannon, R.J. Black, D.H. Brewster, D.W. Huws, C. White, P. Finan, A. Bonaventure, H. Carreira, V. Di Carlo, R. Harewood, K. Liu, L. Montel, M. Nikšić, B. Rachet, N. Sanz, D. Spika, R. Stephens, M. Peake, E. Chalker, L. Newman, D. Baker, M.J. Soeberg, J. Aitken, C. Scott, B.C. Stokes, A. Venn, H. Farrugia, G.G. Giles, T. Threlfall, D. Currow, H. You, J. Hendrix, C. Lewis

Research output: Contribution to journalArticle

Abstract

Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995–2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results During 2005–2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions. © 2016
Original languageEnglish
Pages (from-to)405-413
Number of pages9
JournalGynecologic Oncology
Volume144
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Epidemiology
  • Histology
  • Morphology
  • Ovarain cancer
  • Worldwide
  • adolescent
  • adult
  • aged
  • Article
  • Asia
  • Brenner tumor
  • cancer survival
  • Central America
  • clear cell carcinoma
  • colloid carcinoma
  • comparative study
  • controlled study
  • endometrioid carcinoma
  • epithelium tumor
  • Europe
  • female
  • germ cell tumor
  • histology
  • human
  • human tissue
  • major clinical study
  • mixed tumor
  • morphology
  • North America
  • ovary cancer
  • Pacific islands
  • peritoneum cancer
  • population
  • priority journal
  • retroperitoneal cancer
  • sex cord tumor
  • South America
  • squamous cell carcinoma
  • transitional cell carcinoma
  • trend study
  • undifferentiated carcinoma
  • uterine tube tumor
  • middle aged
  • mortality
  • neoplasm
  • ovary tumor
  • pathology
  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal
  • Neoplasms, Glandular and Epithelial
  • Ovarian Neoplasms
  • Sex Cord-Gonadal Stromal Tumors

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    Matz, M., Coleman, M. P., Sant, M., Chirlaque, M. D., Visser, O., Gore, M., Allemani, C., Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., C.Stefan, D., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul-Sungkur, R., ... Lewis, C. (2017). The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2). Gynecologic Oncology, 144(2), 405-413. https://doi.org/10.1016/j.ygyno.2016.10.019