The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei

Norman J. Carr, Frederic Bibeau, Robert F. Bradley, Peggy Dartigues, Roger M. Feakins, Kim R. Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K. Pai, Manuel Rodriguez-Justo, Leslie H. Sobin, Marie Louise F. van Velthuysen, Rhonda K. Yantiss

Research output: Contribution to journalReview article

Abstract

The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI), and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas and adenocarcinomas. We do not cover goblet cell tumours or neuroendocrine neoplasms in this paper.

Original languageEnglish
Pages (from-to)847-858
Number of pages12
JournalHistopathology
Volume71
Issue number6
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • appendiceal neoplasms
  • appendix
  • peritoneum
  • pseudomyxoma peritonei

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei'. Together they form a unique fingerprint.

  • Cite this

    Carr, N. J., Bibeau, F., Bradley, R. F., Dartigues, P., Feakins, R. M., Geisinger, K. R., Gui, X., Isaac, S., Milione, M., Misdraji, J., Pai, R. K., Rodriguez-Justo, M., Sobin, L. H., van Velthuysen, M. L. F., & Yantiss, R. K. (2017). The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. Histopathology, 71(6), 847-858. https://doi.org/10.1111/his.13324