The history of phenotypic testing in thrombosis and hemostasis

Research output: Contribution to journalArticle

Abstract

This article takes the reader through a journey of the history of the phenotypic tests for hemostasis and thrombosis starting from the most simple (which were based on the visual inspection and recording of the time needed for native whole blood to clot) to the more complex ones based on the addition to plasma of exogenous substances, use of sophisticated coagulometers or synthetic substrates, and use of computer software to record coagulation times or visualize coagulation tracings and thrombin generation curves. One can see how the simple tests evolved over the years and how such old and time-honored tests as thrombin generation and thromboelastography, devised more than 50 years ago and neglected for many years, are now gaining momentum thanks to the progress made by the technology combined with a better understanding of the coagulation mechanisms. This progress notwithstanding, it should be realized that current tests are still somewhat far from being adequate to investigate hemostasis and thrombosis. The challenge in the future will be to devise newer tests mimicking more closely what occurs in vivo.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalSeminars in Thrombosis and Hemostasis
Volume34
Issue number7
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Hemostasis
Thrombosis
History
Thrombin
Thrombelastography
Software
Technology

Keywords

  • APTT
  • Coagulation tests
  • PT
  • Synthetic substrates
  • Thrombin generation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

The history of phenotypic testing in thrombosis and hemostasis. / Tripodi, Armando.

In: Seminars in Thrombosis and Hemostasis, Vol. 34, No. 7, 10.2008, p. 585-592.

Research output: Contribution to journalArticle

@article{b00d91d69cc04beda2b76ecde57c2dc5,
title = "The history of phenotypic testing in thrombosis and hemostasis",
abstract = "This article takes the reader through a journey of the history of the phenotypic tests for hemostasis and thrombosis starting from the most simple (which were based on the visual inspection and recording of the time needed for native whole blood to clot) to the more complex ones based on the addition to plasma of exogenous substances, use of sophisticated coagulometers or synthetic substrates, and use of computer software to record coagulation times or visualize coagulation tracings and thrombin generation curves. One can see how the simple tests evolved over the years and how such old and time-honored tests as thrombin generation and thromboelastography, devised more than 50 years ago and neglected for many years, are now gaining momentum thanks to the progress made by the technology combined with a better understanding of the coagulation mechanisms. This progress notwithstanding, it should be realized that current tests are still somewhat far from being adequate to investigate hemostasis and thrombosis. The challenge in the future will be to devise newer tests mimicking more closely what occurs in vivo.",
keywords = "APTT, Coagulation tests, PT, Synthetic substrates, Thrombin generation",
author = "Armando Tripodi",
year = "2008",
month = "10",
doi = "10.1055/s-0028-1104537",
language = "English",
volume = "34",
pages = "585--592",
journal = "Seminars in Thrombosis and Hemostasis",
issn = "0094-6176",
publisher = "Thieme Medical Publishers",
number = "7",

}

TY - JOUR

T1 - The history of phenotypic testing in thrombosis and hemostasis

AU - Tripodi, Armando

PY - 2008/10

Y1 - 2008/10

N2 - This article takes the reader through a journey of the history of the phenotypic tests for hemostasis and thrombosis starting from the most simple (which were based on the visual inspection and recording of the time needed for native whole blood to clot) to the more complex ones based on the addition to plasma of exogenous substances, use of sophisticated coagulometers or synthetic substrates, and use of computer software to record coagulation times or visualize coagulation tracings and thrombin generation curves. One can see how the simple tests evolved over the years and how such old and time-honored tests as thrombin generation and thromboelastography, devised more than 50 years ago and neglected for many years, are now gaining momentum thanks to the progress made by the technology combined with a better understanding of the coagulation mechanisms. This progress notwithstanding, it should be realized that current tests are still somewhat far from being adequate to investigate hemostasis and thrombosis. The challenge in the future will be to devise newer tests mimicking more closely what occurs in vivo.

AB - This article takes the reader through a journey of the history of the phenotypic tests for hemostasis and thrombosis starting from the most simple (which were based on the visual inspection and recording of the time needed for native whole blood to clot) to the more complex ones based on the addition to plasma of exogenous substances, use of sophisticated coagulometers or synthetic substrates, and use of computer software to record coagulation times or visualize coagulation tracings and thrombin generation curves. One can see how the simple tests evolved over the years and how such old and time-honored tests as thrombin generation and thromboelastography, devised more than 50 years ago and neglected for many years, are now gaining momentum thanks to the progress made by the technology combined with a better understanding of the coagulation mechanisms. This progress notwithstanding, it should be realized that current tests are still somewhat far from being adequate to investigate hemostasis and thrombosis. The challenge in the future will be to devise newer tests mimicking more closely what occurs in vivo.

KW - APTT

KW - Coagulation tests

KW - PT

KW - Synthetic substrates

KW - Thrombin generation

UR - http://www.scopus.com/inward/record.url?scp=58149083612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149083612&partnerID=8YFLogxK

U2 - 10.1055/s-0028-1104537

DO - 10.1055/s-0028-1104537

M3 - Article

C2 - 19085759

AN - SCOPUS:58149083612

VL - 34

SP - 585

EP - 592

JO - Seminars in Thrombosis and Hemostasis

JF - Seminars in Thrombosis and Hemostasis

SN - 0094-6176

IS - 7

ER -